Lower cardiorespiratory fitness contributes to increased insulin resistance and fasting glycaemia in middle-aged South Asian compared with European men living in the UK.
Lower cardiorespiratory fitness contributes to increased insulin resistance and fasting glycaemia in middle-aged South Asian compared with European men living in the UK.
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DOI：
10.1007/s00125-013-2969-y
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发表时间：
2013-10
期刊：
影响因子：
8.2
通讯作者：
Sattar, N.
中科院分区：
文献类型：
--
作者：
Ghouri, N.;Purves, D.;McConnachie, A.;Wilson, J.;Gill, J. M. R.;Sattar, N.
关键词：
本研究旨在确定与生活在英国的白色欧洲男性相比，南亚男性的胰岛素抵抗和空腹血糖增加在多大程度上是由于心肺适能（最大摄氧量[]）和体力活动降低所致。100名南亚和100名年龄和BMI匹配的欧洲男性，年龄在40-70岁之间，未诊断为糖尿病，空腹采血测量葡萄糖浓度、HOMA估计的胰岛素抵抗（HOMAIR）以及其他风险因素，并评估体力活动（使用加速度计）、体型和组成、人口统计学和其他生活方式因素。对于13名南亚和1名欧洲男性，HbA 1c水平>6.5%（>48 mmol/mol），表明潜在的未诊断糖尿病;这些男性被排除在分析之外。线性回归模型被用来确定在何种程度上的身体大小和组成，健身和体力活动变量解释南亚和欧洲男性之间的HOMAIR和空腹血糖的差异。南亚人的HOMAIR和空腹血糖分别比欧洲人高67%（p < 0.001）和3%（p < 0.018）。南亚人较低、较低的体力活动和较高的总肥胖分别解释了68%（95% CI 45%，91%）、29%（11%，46%）和52%（30%，80%）的HOMAIR种族差异，共同解释了83%（50%，119%）（所有p < 0.001）。总体肥胖程度较低和较高分别解释了空腹血糖种族差异的61%（9%，111%）和39%（9%，76%）（综合效应63% [8%，115%];所有p < 0.05）。与生活在英国的欧洲男性相比，在南亚中年男性中，较低的心肺功能是与过度胰岛素抵抗和空腹血糖相关的关键因素。本文的在线版本（doi：10.1007/s 00125 -013-2969-y）包含同行评审但未经编辑的补充材料，可供授权用户使用。
This study aimed to determine the extent to which increased insulin resistance and fasting glycaemia in South Asian men, compared with white European men, living in the UK, was due to lower cardiorespiratory fitness (maximal oxygen uptake []) and physical activity. One hundred South Asian and 100 age- and BMI-matched European men without diagnosed diabetes, aged 40–70 years, had fasted blood taken for measurement of glucose concentration, HOMA-estimated insulin resistance (HOMAIR), plus other risk factors, and underwent assessment of physical activity (using accelerometry), , body size and composition, and demographic and other lifestyle factors. For 13 South Asian and one European man, HbA1c levels were >6.5% (>48 mmol/mol), indicating potential undiagnosed diabetes; these men were excluded from the analyses. Linear regression models were used to determine the extent to which body size and composition, fitness and physical activity variables explained differences in HOMAIR and fasting glucose between South Asian and European men. HOMAIR and fasting glucose were 67% (p < 0.001) and 3% (p < 0.018) higher, respectively, in South Asians than Europeans. Lower , lower physical activity and greater total adiposity in South Asians individually explained 68% (95% CI 45%, 91%), 29% (11%, 46%) and 52% (30%, 80%), respectively, and together explained 83% (50%, 119%) (all p < 0.001) of the ethnic difference in HOMAIR. Lower and greater total adiposity, respectively, explained 61% (9%, 111%) and 39% (9%, 76%) (combined effect 63% [8%, 115%]; all p < 0.05) of the ethnic difference in fasting glucose. Lower cardiorespiratory fitness is a key factor associated with the excess insulin resistance and fasting glycaemia in middle-aged South Asian, compared with European, men living in the UK. The online version of this article (doi:10.1007/s00125-013-2969-y) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
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DOI：
10.1097/00005768-199805000-00021
发表时间：
1998-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Freedson, PS;Melanson, E;Sirard, J
通讯作者：
Sirard, J
DOI：
10.1249/mss.0b013e3180a76de5
发表时间：
2007-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Hagstromer, Maria;Oja, Pekka;Sjostrom, Michael
通讯作者：
Sjostrom, Michael
DOI：
10.1097/00005768-199802000-00013
发表时间：
1998-02-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Bouchard, C;Daw, EW;Wilmore, JH
通讯作者：
Wilmore, JH
影响因子：
3.5
作者：
Mukhopadhyay, B;Forouhi, NG;Sattar, N
通讯作者：
Sattar, N
影响因子：
4.1
作者：
Ceaser, Tyrone G.;Fitzhugh, Eugene C.;Bassett, David R., Jr.
通讯作者：
Bassett, David R., Jr.