Dexamethasone‐induced selective inhibition of the central μ opioid receptor: functional in vivo and in vitro evidence in rodents
Dexamethasone‐induced selective inhibition of the central μ opioid receptor: functional in vivo and in vitro evidence in rodents
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地塞米松诱导的中枢 μ 阿片受体选择性抑制：啮齿类动物体内和体外功能证据
DOI：
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发表时间：
1994
影响因子：
7.3
通讯作者：
A. Loizzo
中科院分区：
文献类型：
--
作者：
S. Pieretti;A. Giannuario;M. R. Domenici;S. Sagratella;A. Capasso;L. Sorrentino;A. Loizzo
内源性皮质类固醇和阿片类药物参与机体的许多功能，包括镇痛、大脑兴奋性、应激等。因此，我们认为获得皮质类固醇和特定阿片受体亚群之间功能相互作用的信息是重要的。我们发现，系统给药（i.p）强效的合成皮质类固醇，地塞米松，减少高选择性μ激动剂，DAMGO或选择性较低的μ激动剂吗啡和β -内啡肽诱导的抗痛感，相反，地塞米松对δ1激动剂，DPDPE和δ2激动剂德尔松II诱导的抗痛感影响很小或没有影响。地塞米松可增强k受体激动剂U50,488诱导的抗惊觉作用。在大鼠海马片脑兴奋性的体外模型实验中，地塞米松强烈地阻止了CA1记录的场电位持续时间的增加，以及μ受体激动剂诱导的额外群体尖峰的出现和数量。在两种模型中，环己亚胺（一种蛋白质合成抑制剂）预处理可以阻止地塞米松对μ阿片受体激动剂的拮抗作用。我们的数据表明，在啮齿类动物大脑中，至少在μ受体水平上，皮质类固醇和阿片系统之间存在重要的功能相互作用，而δ和k受体则以不同的方式调节。
1 Endogenous corticosteroids and opioids are involved in many functions of the organism, including analgesia, cerebral excitability, stress and others. Therefore, we considered it important to gain information on the functional interaction between corticosteroids and specific opioid receptor subpopulations. 2 We have found that systemic administration (i.p.) of the potent synthetic corticosteroid, dexamethasone, reduced the antinociception induced by the highly selective μ agonist, DAMGO or by less selective μ agonists morphine and β‐endorphin administered i.e.v., On the contrary dexamethasone exerted little or no influence on the antinociception induced by a δ1 agonist, DPDPE and a δ2 agonist deltorphin II. Dexamethasone potentiated the antinociception induced by the k agonist, U50,488. 3 In experiments performed in an in vitro model of cerebral excitability in the rat hippocampal slice, dexamethasone strongly prevented both the increase of the duration of the field potential recorded in CA1, and the appearance and number of additional population spikes induced by μ receptor agonists. 4 In both models pretreatment with cycloheximide, a protein synthesis inhibitor, prevented the antagonism by dexamethasone of responses to the μ opioid agonists. 5 Our data indicate that in the rodent brain there is an important functional interaction between the corticosteroid and the opioid systems at least at the μ receptor level, while δ and k receptors are modulated in different ways.
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强啡肽对大鼠海马锥体细胞的电生理作用。
影响因子：
5
作者：
Moises,HC;Walker,JM
通讯作者：
Walker,JM
鞘内注射胆囊收缩素选择性拮抗小鼠脑室内β-内啡肽诱导的甩尾抑制。
DOI：
--
发表时间：
1992
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Tseng,LF;Collins,KA
通讯作者：
Collins,KA
DOI：
10.1073/pnas.78.10.6517
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
SPIESS, J;RIVIER, J;VALE, W
通讯作者：
VALE, W
大鼠海马齿状回和 CA1 区阿片受体介导的反应。
DOI：
--
发表时间：
1988
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Neumaier,JF;Mailheau,S;Chavkin,C
通讯作者：
Chavkin,C
kappa-阿片受体激动剂对吗啡首次使用和吗啡耐受大鼠吗啡镇痛的影响。
影响因子：
5
作者：
Ramarao,P;JablonskiJr,HI;Rehder,KR;Bhargava,HN
通讯作者：
Bhargava,HN