The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy.
The Hypoxic Microenvironment of Breast Cancer Cells Promotes Resistance in Radiation Therapy.
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DOI：
10.3389/fonc.2020.629422
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发表时间：
2020
影响因子：
4.7
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Gilreath C;Boerma M;Qin Z;Hudson MK;Wang S
美国癌症协会估计，2020年美国预计将有279，100例新发乳腺癌病例，预计将有42，690例乳腺癌死亡。这包括预计将被诊断的估计276 480名妇女。放射治疗，也称为电离放射治疗，是治疗乳腺癌最常用的方法之一。虽然放射疗法用于治疗超过50%的所有癌症病例，但肿瘤对电离辐射的抗性对有效的癌症治疗提出了重大挑战。大多数肿瘤细胞处于缺氧微环境中，这促进了对放射治疗的抵抗。除了辐射抗性之外，低氧微环境还促进癌症增殖和转移。本文就乳腺癌肿瘤的低氧微环境、相关信号通路、乳腺癌干细胞样细胞以及乳腺癌对放射治疗的抵抗等方面进行综述。我们对肿瘤缺氧和缺氧途径的理解的最新进展可能有助于我们开发新的策略来增加放射治疗中的癌症控制。
The American Cancer Society has estimated an expected 279,100 new breast cancer cases, and an expected 42,690 breast cancer deaths in the U.S. for the year 2020. This includes an estimated 276,480 women who are expected to be diagnosed. Radiation therapy, also called ionizing radiation therapy, is one of the most frequently used methods in the treatment of breast cancer. While radiation therapy is used in the treatment of more than 50% of all cancer cases, tumor resistance to ionizing radiation presents a major challenge for effective cancer treatment. Most tumor cells are in a hypoxic microenvironment that promotes resistance to radiation therapy. In addition to radiation resistance, the hypoxic microenvironment also promotes cancer proliferation and metastasis. In this review, we will discuss the hypoxic microenvironment of breast cancer tumors, related signaling pathways, breast cancer stem-like cells, and the resistance to radiation therapy. Recent developments in our understanding of tumor hypoxia and hypoxic pathways may assist us in developing new strategies to increase cancer control in radiation therapy.
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