The association between the serum uric acid to creatinine ratio and all-cause mortality in elderly hemodialysis patients.
The association between the serum uric acid to creatinine ratio and all-cause mortality in elderly hemodialysis patients.
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DOI：
10.1186/s12882-022-02798-4
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发表时间：
2022-05-06
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影响因子：
2.3
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中科院分区：
文献类型：
--
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老年血液透析患者的死亡率高于非老年血液透析患者。最近的研究表明，血清尿酸与肌酐比值（SUA/Scr）与普通成人的全因死亡率有关。本研究的目的是探讨老年血液透析患者的SUA/Scr与全因和心血管疾病死亡率之间的关系。本研究纳入2015年1月至2019年12月期间在泰州市第二人民医院每周接受血液透析超过8小时且持续至少3个月的患者222例（≥60岁）。临床特征包括年龄、性别和身高等，从血液透析数据库中获取。血液透析前采集白蛋白（ALB）、总胆固醇（TC）、血清尿酸（SUA）、血清肌酐（Scr）等实验室数据，采用全自动生化分析仪进行分析。在随访期间记录生存信息。采用多重Cox回归分析SUA/Scr与全因死亡率之间的关系。各组生存率采用Kaplan-Meier法计算，生存曲线比值采用log-rank检验分析。SUA/Scr对预测全因死亡风险的贡献通过净再分类改善（NRI）来评估。在19个月的观察期间，78例患者死亡。未存活组患者的年龄（P < 0.001）、体重指数（BMI） （P = 0.004）、血清肌酐（P = 0.005）和前白蛋白（P = 0.006）均显著高于存活组患者。在调整年龄、性别、BMI、前白蛋白、透析年份、透析频率、单池Kt/V （spKt/V）、DM、高血压和合共病后，较高的SUA/Scr比值与较高的全因死亡风险独立相关（HR: 1.292; 95% CI: 1.013-1.648; P = 0.039）。在老年血液透析患者中，SUA/Scr对全因死亡率的预测价值优于SUA（加性NRI = 0.214, P = 0.015）和Scr（加性NRI = 0.476, P < 0.001）。血清尿酸/肌酐比值与老年血液透析患者的全因死亡率密切相关，比单独使用SUA或Scr更具有预测性。在线版本包含补充材料，可在10.1186/s12882-022-02798-4获得。
Elderly hemodialysis patients have a higher rate of mortality than nonelderly hemodialysis patients. Recent studies shown that the serum uric acid to creatinine ratio (SUA/Scr) was associated with all-cause mortality in general adults. The purpose of the present study was to investigate the association between the SUA/Scr and all-cause and cardiovascular disease mortality among elderly hemodialysis patients. A total of 222 patients (≥ 60 years) who received hemodialysis more than 8 h per week at Taizhou Second People’s Hospital for at least 3 months were enrolled in the present study from January 2015 to December 2019. Clinical characteristics including age, sex and height et. al, were obtained from the hemodialysis database. The laboratory data, including albumin (ALB), total cholesterol (TC), serum uric acid (SUA), serum creatinine (Scr) and so on, were collected before hemodialysis and analyzed by automatic biochemical analyzer. Survival information was recorded during the follow-up period. Multiple Cox regression was carried out to analyze the association between SUA/Scr and all-cause mortality. The survival rate of each group was calculated by the Kaplan–Meier method, and the ratio of survival curves was analyzed by the log-rank test. The contribution of SUA/Scr for predicting all-cause mortality risk was evaluated by net reclassification improvement (NRI). During the 19-month observation period, 78 patients died. Individuals in the nonsurviving group had significantly older ages (P < 0.001), body mass index (BMI) (P = 0.004), serum creatinine (P = 0.005) and prealbumin (P = 0.006) than surviving patients. After adjusting for age, sex, BMI, prealbumin, dialysis vintage, dialysis frequency, single-pool Kt/V (spKt/V), DM, hypertension and comorbidities, a higher ratio of SUA/Scr was independently associated with a higher risk of all-cause mortality (HR: 1.292; 95% CI: 1.013–1.648; P = 0.039). The predict value on all-cause mortality of SUA/Scr was superior to SUA (additive NRI = 0.214, P = 0.015) and Scr (additive NRI = 0.476, P < 0.001) among elderly hemodialysis patients. The serum uric acid to creatinine ratio is strongly associated with all-cause mortality in elderly hemodialysis patients which is more predictive than SUA or Scr alone. The online version contains supplementary material available at 10.1186/s12882-022-02798-4.
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影响因子：
3.7
作者：
Canaud B;Granger Vallée A;Molinari N;Chenine L;Leray-Moragues H;Rodriguez A;Chalabi L;Morena M;Cristol JP
通讯作者：
Cristol JP
DOI：
10.2215/cjn.00670111
发表时间：
2011-10-01
影响因子：
9.8
作者：
Latif, Walead;Karaboyas, Angelo;Saran, Rajiv
通讯作者：
Saran, Rajiv
影响因子：
2
作者：
Antunovic, Tanja;Stefanovic, Aleksandra;Stojanov, Marina
通讯作者：
Stojanov, Marina
影响因子：
2.1
作者：
Seo, Yoo Bin;Han, A. Lum
通讯作者：
Han, A. Lum
影响因子：
7.2
作者：
ABBOTT, RD;BRAND, FN;CASTELLI, WP
通讯作者：
CASTELLI, WP