Comparison of diagnostic accuracy of clinical measures of breast cancer-related lymphedema: area under the curve.
Comparison of diagnostic accuracy of clinical measures of breast cancer-related lymphedema: area under the curve.
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DOI：
10.1016/j.apmr.2010.11.017
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发表时间：
2011-04
影响因子：
4.3
通讯作者：
Dodd, Marylin J.
中科院分区：
文献类型：
--
作者：
Smoot, Betty J.;Wong, Josephine F.;Dodd, Marylin J.
比较乳腺癌相关性水肿（BCRL）的诊断准确性。横断面设计比较临床指标与既往BCRL诊断标准。加州大学旧金山弗朗西斯科转化科学临床研究中心。年龄大于18岁且乳腺癌治疗后超过6个月的女性（n=141; 70例BCRL，71例无BCRL）。不适用因采用灵敏度、特异性、受试者工作特征曲线和曲线下面积（AUC）评价准确性。共有141名妇女被归类为有（n=70）或没有（n=71）BCRL的基础上，过去的诊断由卫生保健提供者，这是作为参考标准。连续结果的ROC曲线分析得出AUC为0.68至0.88（P<.001）;的物理测量生物阻抗谱产生了最高的准确性与AUC的0.88（95%置信区间，对于优势臂为受累臂的女性，使用2cm诊断临界值识别先前诊断的BCRL的准确性最低（AUC，0.54 - 0.65）。我们的研究结果支持使用生物阻抗谱评估现有的BCRL。细化诊断临界值可以提高诊断的准确性，并保证进一步的调查。
To compare diagnostic accuracy of measures of breast cancer–related lymphedema (BCRL). Cross-sectional design comparing clinical measures with the criterion standard of previous diagnosis of BCRL. University of California San Francisco Translational Science Clinical Research Center. Women older than 18 years and more than 6 months posttreatment for breast cancer (n=141; 70 with BCRL, 71 without BCRL). Not applicable. Sensitivity, specificity, receiver operator characteristic curve, and area under the curve (AUC) were used to evaluate accuracy. A total of 141 women were categorized as having (n=70) or not having (n=71) BCRL based on past diagnosis by a health care provider, which was used as the reference standard. Analyses of ROC curves for the continuous outcomes yielded AUC of .68 to .88 (P<.001); of the physical measures bioimpedance spectroscopy yielded the highest accuracy with an AUC of .88 (95% confidence interval, .80–.96) for women whose dominant arm was the affected arm. The lowest accuracy was found using the 2-cm diagnostic cutoff score to identify previously diagnosed BCRL (AUC, .54–.65). Our findings support the use of bioimpedance spectroscopy in the assessment of existing BCRL. Refining diagnostic cutoff values may improve accuracy of diagnosis and warrant further investigation.
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影响因子：
3.8
作者：
Hayes, S;Cornish, B;Newman, B
通讯作者：
Newman, B
影响因子：
45.3
作者：
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