Update on research and treatment of premenstrual dysphoric disorder.
Update on research and treatment of premenstrual dysphoric disorder.
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DOI：
10.1080/10673220902891836
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发表时间：
2009
影响因子：
3.8
通讯作者：
Eriksson E
中科院分区：
文献类型：
--
作者：
Cunningham J;Yonkers KA;O'Brien S;Eriksson E
许多女性在她们的生育年龄经历了一些情绪，行为。或月经前一周出现身体症状。症状负担的程度存在差异，一些妇女出现轻微症状，而少数妇女出现严重和使人虚弱的症状。据估计，有5%-8%的绝经前妇女的工作或社交功能受到严重经前综合症的影响。这一组中的许多女性符合经前焦虑症(PMDD)的诊断标准。在患有PMDD的女性中，情绪和行为症状占主导地位，如易怒、抑郁、紧张和情绪不稳定。包括乳房压痛和腹胀在内的躯体症状也会破坏女性的整体功能和生活质量。最近的证据表明，个体对性腺激素水平周期性变化的敏感性可能会使某些女性更容易经历这些情绪、行为和躯体症状。治疗包括：间歇或在整个月经周期服用的5-羟色胺再摄取抑制剂类的抗抑郁药；抑制卵巢周期的药物；以及含有新型孕激素的新型口服避孕药。(哈维·瑞夫精神病学2009；17：120-137。)
Many women in their reproductive years experience some mood, behavioral. or physical symptoms in the week prior to menses. Variability exists in the level of symptom burden in that some women experience mild symptoms, whereas a small minority experience severe and debilitating symptoms. For an estimated 5%–8% of premenopausal women, work or social functioning are affected by severe premenstrual syndrome. Many women in this group meet diagnostic criteria for premenstrual dysphoric disorder (PMDD). Among women who suffer from PMDD, mood and behavioral symptoms such as irritability, depressed mood, tension, and labile mood dominate. Somatic complaints, including breast tenderness and bloating, also can prove disruptive to women's overall functioning and quality of life. Recent evidence suggests that individual sensitivity to cyclical variations in levels of gonadal hormones may predispose certain women to experience these mood, behavioral, and somatic symptoms. Treatments include: antidepressants of the serotonin reuptake inhibitor class, taken intermittently or throughout the menstrual cycle; medications that suppress ovarian cyclicity; and newer oral contraceptives with novel progestins. (Harv Rev Psychiatry 2009;17:120–137.)
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