FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function.
FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function.
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DOI：
10.3389/fnsys.2023.1212213
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发表时间：
2023
影响因子：
3
通讯作者：
Davis, Christopher J.
中科院分区：
文献类型：
--
作者：
Gerstner, Jason R.;Flores, Carlos C.;Lefton, Micah;Rogers, Brooke;Davis, Christopher J.
睡眠和昼夜节律在动物门中广泛存在，并影响神经可塑性和认知功能。然而，涉及这些过程的少数遗传学保守的细胞和分子途径主要集中在神经元细胞上。对这些主题的研究传统上将睡眠稳态行为与昼夜休息活动节律分开。在这里，我们提出了另一种观点，即影响行为状态，可塑性和认知的睡眠和昼夜节律整合的机制存在于神经胶质细胞中。脑型脂肪酸结合蛋白FABP 7是脂质伴侣蛋白大家族的一部分，其调节脂肪酸的亚细胞运输以实现广泛的细胞功能，包括基因表达、生长、存活、炎症和代谢。FABP 7在中枢神经系统的神经胶质细胞中富集，并且已被证明是涉及睡眠/觉醒调节和认知处理的时钟控制基因。已知FABP 7影响基因转录、细胞生长，并且其在精细突触周星形胶质细胞过程（PAP）中的亚细胞定位基于一天中的时间而变化。未来的研究确定FABP 7对行为状态和昼夜节律依赖的可塑性和认知过程的影响，以及与神经胶质相互作用，脂质储存和血脑屏障完整性相关的细胞和分子机制的功能后果将对我们了解基本的睡眠功能很重要。考虑到睡眠障碍与神经系统疾病的共病性，这些研究对于我们理解这些疾病如何影响睡眠或受睡眠影响的病因学和病理生理学也很重要。
Sleep and circadian rhythms are observed broadly throughout animal phyla and influence neural plasticity and cognitive function. However, the few phylogenetically conserved cellular and molecular pathways that are implicated in these processes are largely focused on neuronal cells. Research on these topics has traditionally segregated sleep homeostatic behavior from circadian rest-activity rhythms. Here we posit an alternative perspective, whereby mechanisms underlying the integration of sleep and circadian rhythms that affect behavioral state, plasticity, and cognition reside within glial cells. The brain-type fatty acid binding protein, FABP7, is part of a larger family of lipid chaperone proteins that regulate the subcellular trafficking of fatty acids for a wide range of cellular functions, including gene expression, growth, survival, inflammation, and metabolism. FABP7 is enriched in glial cells of the central nervous system and has been shown to be a clock-controlled gene implicated in sleep/wake regulation and cognitive processing. FABP7 is known to affect gene transcription, cellular outgrowth, and its subcellular localization in the fine perisynaptic astrocytic processes (PAPs) varies based on time-of-day. Future studies determining the effects of FABP7 on behavioral state- and circadian-dependent plasticity and cognitive processes, in addition to functional consequences on cellular and molecular mechanisms related to neural-glial interactions, lipid storage, and blood brain barrier integrity will be important for our knowledge of basic sleep function. Given the comorbidity of sleep disturbance with neurological disorders, these studies will also be important for our understanding of the etiology and pathophysiology of how these diseases affect or are affected by sleep.
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影响因子：
3.7
作者：
Gerstner JR;Vanderheyden WM;Shaw PJ;Landry CF;Yin JC
通讯作者：
Yin JC
影响因子：
5.2
作者：
Barca-Mayo O;López M
通讯作者：
López M
影响因子：
9.2
作者：
Bernardinelli, Yann;Randall, Jerome;Muller, Dominique
通讯作者：
Muller, Dominique
DOI：
10.1016/j.cub.2020.10.012
发表时间：
2021-01-11
期刊：
Current biology : CB
影响因子：
--
作者：
Blum ID;Keleş MF;Baz ES;Han E;Park K;Luu S;Issa H;Brown M;Ho MCW;Tabuchi M;Liu S;Wu MN
通讯作者：
Wu MN
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS