The role of complement in ocular pathology.
The role of complement in ocular pathology.
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DOI：
10.1007/s00281-008-0110-y
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发表时间：
2008-04
影响因子：
9
通讯作者：
Bora, Puran S.
中科院分区：
文献类型：
--
作者：
Bora, Nalini S.;Jha, Purushottam;Bora, Puran S.
关键词：
功能活性的补体系统和补体调节蛋白存在于正常人和啮齿动物的眼睛中。补体激活及其通过眼部补体调节蛋白的调节有助于各种眼部疾病的病理学，包括角膜炎、葡萄膜炎和年龄相关性黄斑变性。此外，年龄相关性黄斑变性与某些补体成分/补体调节蛋白基因多态性之间的密切关系现已得到充分确立。天然存在的补体调节蛋白的重组形式已经在动物模型中被开发用于治疗这些眼部疾病。希望在未来的重组补体调节蛋白将被用作新的治疗药物在临床上用于治疗角膜炎，葡萄膜炎，和年龄相关性黄斑变性。
Functionally active complement system and complement regulatory proteins are present in the normal human and rodent eye. Complement activation and its regulation by ocular complement regulatory proteins contribute to the pathology of various ocular diseases including keratitis, uveitis and age-related macular degeneration. Furthermore, a strong relationship between age-related macular degeneration and polymorphism in the genes of certain complement components/complement regulatory proteins is now well established. Recombinant forms of the naturally occurring complement regulatory proteins have been exploited in the animal models for treatment of these ocular diseases. It is hoped that in the future recombinant complement regulatory proteins will be used as novel therapeutic agents in the clinic for the treatment of keratitis, uveitis, and age-related macular degeneration.
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DOI：
10.1073/pnas.0501536102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Hageman, GS;Anderson, DH;Allikmets, R
通讯作者：
Allikmets, R
影响因子：
4.4
作者：
Bora, Nalini S.;Kaliappan, Sankaranarayanan;Bora, Puran S.
通讯作者：
Bora, Puran S.
DOI：
10.1016/0167-5699(91)90009-i
发表时间：
1991-09-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
FRANK, MM;FRIES, LF
通讯作者：
FRIES, LF
DOI：
10.1016/0167-5699(87)90167-8
发表时间：
1987-07-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
ATKINSON, JP;FARRIES, T
通讯作者：
FARRIES, T
影响因子：
5.4
作者：
Bora, PS;Kaliappan, S;Bora, NS
通讯作者：
Bora, NS