Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex.
Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex.
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DOI：
10.1038/s41467-018-03676-0
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发表时间：
2018-04-24
影响因子：
16.6
通讯作者：
LaSalle JM
中科院分区：
文献类型：
--
作者：
Coulson RL;Yasui DH;Dunaway KW;Laufer BI;Vogel Ciernia A;Zhu Y;Mordaunt CE;Totah TS;LaSalle JM
生理过程的节律振荡依赖于昼夜节律钟和昼夜环境的整合。DNA甲基化在表观遗传学上响应于日常节律，因为脑中CpG二核苷酸的子集表现出昼夜节律甲基化。在这里，我们显示了一个主要的遗传效应，在小鼠Snord 116缺失模型的印记疾病普拉德-威利综合征（PWS）的节奏甲基化。在野生型皮质中鉴定出超过23，000个昼夜节律的CpG，在PWS中几乎所有都丢失或相移。在甲基化、转录和染色质水平上观察到Temple/Kagami-Ogata综合征基因座的第二印迹Snord簇的昼夜节律失调，提供了串扰的机制证据。通过PWS小鼠昼夜表观遗传变化鉴定的基因与人脑中的节律和PWS特异性基因重叠，并富集了PWS相关的表型和途径。这些结果支持所提出的印记和睡眠之间的进化关系，并建议可能的时间疗法在治疗PWS和相关疾病。许多基因在大脑的昼夜节律中心具有振荡的基因表达模式。本研究显示了在普拉德-威利综合征小鼠模型中皮质昼夜DNA甲基化振荡，并描述了基因表达和染色质致密化的相应变化。
Rhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is epigenetically responsive to daily rhythms, as a subset of CpG dinucleotides in brain exhibit diurnal rhythmic methylation. Here, we show a major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader–Willi syndrome (PWS). More than 23,000 diurnally rhythmic CpGs are identified in wild-type cortex, with nearly all lost or phase-shifted in PWS. Circadian dysregulation of a second imprinted Snord cluster at the Temple/Kagami-Ogata syndrome locus is observed at the level of methylation, transcription, and chromatin, providing mechanistic evidence of cross-talk. Genes identified by diurnal epigenetic changes in PWS mice overlapped rhythmic and PWS-specific genes in human brain and are enriched for PWS-relevant phenotypes and pathways. These results support the proposed evolutionary relationship between imprinting and sleep, and suggest possible chronotherapy in the treatment of PWS and related disorders. Many genes have oscillating gene expression pattern in circadian centers of the brain. This study shows cortical diurnal DNA methylation oscillation in a mouse model of Prader-Willi syndrome, and describes corresponding changes in gene expression and chromatin compaction.
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影响因子：
14.9
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
通讯作者：
Ma'ayan A
影响因子：
5.2
作者：
Bieth, Eric;Eddiry, Sanaa;Tauber, Maithe
通讯作者：
Tauber, Maithe
DOI：
10.1126/science.1198125
发表时间：
2011-03-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Feng D;Liu T;Sun Z;Bugge A;Mullican SE;Alenghat T;Liu XS;Lazar MA
通讯作者：
Lazar MA
DOI：
10.1016/bs.irrdd.2016.07.005
发表时间：
2016-01-01
期刊：
INTERNATIONAL REVIEW OF RESEARCH IN DEVELOPMENTAL DISABILITIES, VOL 51
影响因子：
--
作者：
Esbensen, A. J.;Schwichtenberg, A. J.
通讯作者：
Schwichtenberg, A. J.
影响因子：
3.7
作者：
Ding, Feng;Li, Hong Hua;Zhang, Shengwen;Solomon, Nicola M.;Camper, Sally A.;Cohen, Pinchas;Francke, Uta
通讯作者：
Francke, Uta