Leached Compounds from Smoked Cigarettes and Their Potential for Bioaccumulation in Rainbow Trout (Oncorhynchus mykiss).
Leached Compounds from Smoked Cigarettes and Their Potential for Bioaccumulation in Rainbow Trout (Oncorhynchus mykiss).
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DOI：
10.1021/acs.chemrestox.3c00167
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发表时间：
2023-11-20
影响因子：
4.1
通讯作者：
Hoh, Eunha
中科院分区：
文献类型：
--
作者：
Richardot, William H.;Yabes, Lenard;Wei, Hung-Hsu;Dodder, Nathan G.;Watanabe, Kayo;Cibor, Adrienne;Schick, Suzaynn F.;Novotny, Thomas E.;Gersberg, Richard;Hoh, Eunha
烟头是世界范围内最普遍的垃圾形式之一，在水生环境中沉积时可能会浸出有毒化合物。以往的研究表明，吸烟的香烟浸出液对水生生物是有毒的。然而，来自浸漏液的特定生物可利用化学品以及人类和野生动物通过食物链接触的可能性尚不清楚。采用基于GC×GC/TOF-MS的非靶向分析方法，确认了43种化合物在暴露于水源时从吸烟香烟中浸出。此外，有机污染物在食用鱼，虹鳟鱼（虹鳟鱼）的生物累积潜力进行了评估，通过直接暴露于0.5 CB/L的香烟的浸出液28天。与对照组相比，暴露组虹鳟鱼的鱼量显著减少（χ2（1）= 5.3，p = 0.021）。对代表性鱼类组织进行的非靶向和靶向化学分析均鉴别出四种烟草生物碱：尼古丁、二烯烟碱、麦斯明和2，2 ′-联吡啶。其平均组织浓度分别为466、55.4、94.1和70.8纳克/克。这项研究确定了从吸烟中浸出的化合物，并证明了虹鳟鱼对特定化学物质的吸收，从而表明在食物网中积累的潜力，导致人类和野生动物接触。
Cigarette butts are one of the most prevalent forms of litter worldwide and may leach toxic compounds when deposited in aquatic environments. Previous studies demonstrated that smoked cigarette leachate is toxic toward aquatic organisms. However, the specific bioavailable chemicals from the leachate and the potential for human and wildlife exposure through the food chain were unknown. Using a nontargeted analytical approach based on GC×GC/TOF-MS, 43 compounds were confirmed to leach from smoked cigarettes when exposed to a water source. Additionally, the bioaccumulation potential of organic contaminants in an edible fish, rainbow trout (Oncorhynchus mykiss), was assessed through direct exposure to the leachate of smoked cigarettes at 0.5 CB/L for 28 days. There was a significant reduction in fish mass among the exposed rainbow trout vs the control group (χ2 (1) = 5.3, p = 0.021). Both nontargeted and targeted chemical analysis of representative fish tissue identified four tobacco alkaloids, nicotine, nicotyrine, myosmine, and 2,2′-bipyridine. Their average tissue concentrations were 466, 55.4, 94.1, and 70.8 ng/g, respectively. This study identifies leached compounds from smoked cigarettes and demonstrates the uptake of specific chemicals in rainbow trout, thus suggesting a potential for accumulation in food webs, resulting in human and wildlife exposure.
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影响因子：
9.8
作者：
Ashfaq, Muhammad;Li, Yan;Sun, Qian
通讯作者：
Sun, Qian
影响因子：
5.8
作者：
Dsikowitzky, L.;Strater, M.;Schwarzbauer, J.
通讯作者：
Schwarzbauer, J.
影响因子：
3.1
作者：
Chang, Daniel;Richardot, William H.;Sutton, Rebecca
通讯作者：
Sutton, Rebecca
影响因子：
6.1
作者：
Deroux, JM;Gonzalez, C;Kovacsik, G
通讯作者：
Kovacsik, G
影响因子：
12.8
作者：
Kalscheur, Kathryn N.;Penskar, Rebecca R.;Gray, Kimberly A.
通讯作者：
Gray, Kimberly A.