Effects of vanadium-containing compounds on membrane lipids and on microdomains used in receptor-mediated signaling.
Effects of vanadium-containing compounds on membrane lipids and on microdomains used in receptor-mediated signaling.
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DOI：
10.1002/cbdv.200890144
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发表时间：
2008-08
影响因子：
2.9
通讯作者：
Crans, Debbie C.
中科院分区：
文献类型：
--
作者：
Roess, Deborah A.;Smith, Steven M. L.;Winter, Peter;Zhou, Jun;Dou, Ping;Baruah, Bharat;Trujillo, Alejandro M.;Levinger, Nancy E.;Yang, Xioda;Barisas, B. George;Crans, Debbie C.
越来越多的证据表明，质膜微区参与胰岛素受体功能。此外，这些结构（通常富含鞘磷脂和胆固醇）的破坏导致胰岛素抵抗。胰岛素抵抗的治疗策略包括使用钒化合物，其已在动物模型中显示出增强胰岛素反应性。钒化合物对膜脂组织的直接作用可能是提高胰岛素作用的一个可能机制。脂质组织的这些变化促进胰岛素受体和其他受体分配到膜微区，在膜微区中受体具有最佳功能。为了探索这种可能性，我们使用了几种涉及钒配合物的策略，例如[VO 2dipic]-（吡啶-2，6-二羧基二氧合钒（V））、十钒酸盐（V10 O286-，V10）、BMOV（双（麦芽酚合）氧代钒（IV））和[VO（saltris）]2（2-亚水杨基亚氨基-2-（羟甲基）-1，3-二羟基丙烷-氧代钒（V））。我们的策略包括评价含钒化合物和模型脂质系统之间的相互作用，评价钒化合物对红细胞膜脂质流动性的影响，以及研究含钒化合物对已知使用膜微区作为信号平台的受体启动的信号事件的影响。
There is increasing evidence for the involvement of plasma membrane microdomains in insulin receptor function. Moreover, disruption of these structures, which are typically enriched in sphingomyelin and cholesterol, results in insulin resistance. Treatment strategies for insulin resistance include the use of vanadium compounds which have been shown in animal models to enhance insulin responsiveness. One possible mechanism for insulin-enhancing effects might involve direct effects of vanadium compounds on membrane lipid organization. These changes in lipid organization promote the partitioning of insulin receptors and other receptors into membrane microdomains where receptors are optimally functional. To explore this possibility, we have used several strategies involving vanadium complexes such as [VO2dipic]− (pyridin-2,6-dicarboxylatodioxovanadium(V)), decavanadate (V10O286−, V10), BMOV (bis(maltolato)oxovanadium(IV)) and [VO(saltris)]2 (2-salicylideniminato-2-(hydroxymethyl)-1,3-dihydroxypropane-oxovanadium(V)). Our strategies include an evaluation of interactions between vanadium-containing compounds and model lipid systems, an evaluation of the effects of vanadium compounds on lipid fluidity in erythrocyte membranes, and studies of the effects of vanadium-containing compounds on signaling events initiated by receptors known to use membrane microdomains as signaling platforms.
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影响因子：
15
作者：
Crans, DC;Rithner, CD;Levinger, NE
通讯作者：
Levinger, NE
影响因子：
4.3
作者：
Fantus, IG;Tsiani, E
通讯作者：
Tsiani, E
影响因子：
15
作者：
Liboiron, BD;Thompson, KH;Orvig, C
通讯作者：
Orvig, C
影响因子：
4.6
作者：
Monga, V;Thompson, KH;Orvig, C
通讯作者：
Orvig, C
影响因子：
20.6
作者：
Sakurai, H;Tamura, A;Kiss, T
通讯作者：
Kiss, T