Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway.
Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway.
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DOI：
10.3389/fnsys.2022.963812
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发表时间：
2022
影响因子：
3
通讯作者：
Ingram, Susan L.
中科院分区：
文献类型：
--
作者：
McPherson, Kylie B.;Ingram, Susan L.
下行性疼痛调节通路对伤害性输入发挥重要的双向控制，以抑制和/或促进疼痛的感知。腹外侧导水管周围灰质（vlPAG）整合来自与疼痛感知的伤害性、认知和情感成分的处理相关的许多区域的输入，并且是阿片样物质作用的关键脑区。阿片样物质受体在vlPAG神经元的子集上以及在撞击vlPAG神经元的GABA能和多巴胺能突触前末梢上表达。将阿片样物质显微注射到vlPAG中产生镇痛，并且显微注射阿片样物质受体拮抗剂纳洛酮阻断刺激介导的镇痛，突出了该区域内内源性阿片样物质释放在伤害感受调节中的作用。vlPAG内的内源性阿片样物质作用是复杂的，并且可能依赖于由急性和慢性疼痛刺激激活的特定神经元回路。这篇综述的重点是vlPAG电路内的细胞异质性，并强调了我们对内源性阿片调节下行疼痛调节电路的理解的差距。
The descending pain modulatory pathway exerts important bidirectional control of nociceptive inputs to dampen and/or facilitate the perception of pain. The ventrolateral periaqueductal gray (vlPAG) integrates inputs from many regions associated with the processing of nociceptive, cognitive, and affective components of pain perception, and is a key brain area for opioid action. Opioid receptors are expressed on a subset of vlPAG neurons, as well as on both GABAergic and glutamatergic presynaptic terminals that impinge on vlPAG neurons. Microinjection of opioids into the vlPAG produces analgesia and microinjection of the opioid receptor antagonist naloxone blocks stimulation-mediated analgesia, highlighting the role of endogenous opioid release within this region in the modulation of nociception. Endogenous opioid effects within the vlPAG are complex and likely dependent on specific neuronal circuits activated by acute and chronic pain stimuli. This review is focused on the cellular heterogeneity within vlPAG circuits and highlights gaps in our understanding of endogenous opioid regulation of the descending pain modulatory circuits.
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影响因子：
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