ExpressHeart: Web Portal to Visualize Transcriptome Profiles of Non-Cardiomyocyte Cells.
ExpressHeart: Web Portal to Visualize Transcriptome Profiles of Non-Cardiomyocyte Cells.
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心脏：可视化非心肌细胞转录组图谱的门户网站。
DOI：
10.3390/ijms22168943
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发表时间：
2021-08-19
影响因子：
5.6
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Li G;Luan C;Dong Y;Xie Y;Zentz SC;Zelt R;Roach J;Liu J;Qian L;Li Y;Yang Y
Unveiling the molecular features in the heart is essential for the study of heart diseases. Non-cardiomyocytes (nonCMs) play critical roles in providing structural and mechanical support to the working myocardium. There is an increasing amount of single-cell RNA-sequencing (scRNA-seq) data characterizing the transcriptomic profiles of nonCM cells. However, no tool allows researchers to easily access the information. Thus, in this study, we develop an open-access web portal, ExpressHeart, to visualize scRNA-seq data of nonCMs from five laboratories encompassing three species. ExpressHeart enables comprehensive visualization of major cell types and subtypes in each study; visualizes gene expression in each cell type/subtype in various ways; and facilitates identifying cell-type-specific and species-specific marker genes. ExpressHeart also provides an interface to directly combine information across datasets, for example, generating lists of high confidence DEGs by taking the intersection across different datasets. Moreover, ExpressHeart performs comparisons across datasets. We show that some homolog genes (e.g., Mmp14 in mice and mmp14b in zebrafish) are expressed in different cell types between mice and zebrafish, suggesting different functions across species. We expect ExpressHeart to serve as a valuable portal for investigators, shedding light on the roles of genes on heart development in nonCM cells.
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影响因子：
37.8
作者：
Tucker NR;Chaffin M;Fleming SJ;Hall AW;Parsons VA;Bedi KC Jr;Akkad AD;Herndon CN;Arduini A;Papangeli I;Roselli C;Aguet F;Choi SH;Ardlie KG;Babadi M;Margulies KB;Stegmann CM;Ellinor PT
通讯作者：
Ellinor PT
影响因子：
64.8
作者：
Litviňuková M;Talavera-López C;Maatz H;Reichart D;Worth CL;Lindberg EL;Kanda M;Polanski K;Heinig M;Lee M;Nadelmann ER;Roberts K;Tuck L;Fasouli ES;DeLaughter DM;McDonough B;Wakimoto H;Gorham JM;Samari S;Mahbubani KT;Saeb-Parsy K;Patone G;Boyle JJ;Zhang H;Zhang H;Viveiros A;Oudit GY;Bayraktar OA;Seidman JG;Seidman CE;Noseda M;Hubner N;Teichmann SA
通讯作者：
Teichmann SA
影响因子：
48
作者：
Ramani V;Deng X;Qiu R;Gunderson KL;Steemers FJ;Disteche CM;Noble WS;Duan Z;Shendure J
通讯作者：
Shendure J
影响因子：
64.8
作者：
Nakada, Yuji;Canseco, Diana C.;Sadek, Hesham A.
通讯作者：
Sadek, Hesham A.
影响因子：
37.8
作者：
Nicin, Luka;Abplanalp, Wesley T.;Dimmeler, Stefanie
通讯作者：
Dimmeler, Stefanie