High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma.
High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma.
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DOI：
10.1186/s12931-020-01597-5
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发表时间：
2020-12-14
影响因子：
5.8
通讯作者：
Nishimura Y
中科院分区：
文献类型：
--
作者：
Dokuni R;Nagano T;Jimbo N;Sato H;Kiriu T;Yasuda Y;Yamamoto M;Tachihara M;Kobayashi K;Maniwa Y;Nishimura Y
最近的研究表明，丝氨酸肽酶抑制剂分支E成员2 （SERPINE2）与肿瘤发生有关。然而，SERPINE2的表达及其在肺腺癌中的作用尚不清楚。采用免疫染色法分析74例连续切除的肺腺癌组织中SERPINE2的表达水平。定量PCR检测小干扰RNA （siRNA）对SERPINE2表达的抑制作用。通过细胞数量测定和细胞凋亡测定来阐明SERPINE2在A549和PC9肺癌细胞中的细胞自主功能。SERPINE2高表达患者的总生存率明显低于SERPINE2低表达患者（P = 0.0172）。多因素分析显示SERPINE2表达是与预后不良相关的独立因素（P = 0.03237）。干扰SERPINE2可使A549和PC9细胞数量减少，凋亡增加，提示SERPINE2可作为肺腺癌新的预后标志物。
Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in lung adenocarcinomas are still unknown. The expression levels of SERPINE2 in 74 consecutively resected lung adenocarcinomas were analyzed by using immunostaining. Inhibition of SERPINE2 expression by small interfering RNA (siRNA) was detected by quantitative PCR. Cell number assays and cell apoptosis assays were performed to clarify the cell-autonomous function of SERPINE2 in A549 and PC9 lung cancer cells. The overall survival of patients with high SERPINE2 expression was significantly worse than that of patients with low SERPINE2 expression (P = 0.0172). Multivariate analysis revealed that SERPINE2 expression was an independent factor associated with poor prognosis (P = 0.03237). The interference of SERPINE2 decreased cell number and increased apoptosis in A549 and PC9 cells These results suggest that SERPINE2 can be used as a novel prognostic marker of lung adenocarcinoma.
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