Effects of quality of energy on substrate oxidation in enterally fed, low-birth-weight infants.
Effects of quality of energy on substrate oxidation in enterally fed, low-birth-weight infants.
复制标题
能量质量对肠内喂养的低出生体重婴儿底物氧化的影响。
DOI：
10.1093/ajcn/74.3.374
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
K. Schulze
中科院分区：
文献类型：
--
作者：
S. Kashyap;H. Towers;R. Sahni;K. Ohira;K. Abildskov;K. Schulze
背景
碳水化合物和脂肪在支持需要能量的生理过程（如蛋白质合成和生长）的能力上可能有所不同。如果是这样的话，改变婴儿配方奶粉的成分可能在治疗上是有利的。
目的
我们检验了一个假设，即低出生体重儿饮食中含有65%的非蛋白质能量作为碳水化合物，比饮食中含有35%的非蛋白质能量作为碳水化合物的婴儿氧化相对更多的碳水化合物和相对更少的蛋白质。
设计
62名出生时体重在750 ~ 1600 g之间的低出生体重儿被随机盲法分配到5种配方奶粉中的1种，这些配方奶粉仅在非蛋白质能量的数量和质量上有所不同。对照受试者、第1组和第2组分别接受含有544 kJ x kg（-1）x d（-1）的配方奶粉，其中50%、35%或65%的非蛋白质能量为碳水化合物。第3组和第4组的总能量摄入量为648 kJ x kg（-1）x d（-1），其中35%和65%的非蛋白质能量为碳水化合物。蛋白质摄入量目标为4 g x kg（-1）x d（-1）。通过每两周一次的6小时气体交换和24小时尿氮排泄测量来估计底物氧化。
结果
碳水化合物氧化与碳水化合物摄入量呈正相关（r = 0.71，P < 0.0001），脂肪氧化与碳水化合物摄入量呈负相关（r =-0.46，P < 0.001）。蛋白质氧化与碳水化合物氧化呈负相关（r =-0.42，P < 0.001）。脂肪氧化与蛋白质氧化不相关。接受65%非蛋白质能量作为碳水化合物的婴儿的蛋白质氧化程度低于接受35%非蛋白质能量作为碳水化合物的婴儿。
结论
这些数据支持这样的假设，即在肠内喂养的低出生体重婴儿中，以碳水化合物形式提供的能量比以脂肪形式提供的能量更有效地避免蛋白质氧化。
BACKGROUND
Carbohydrate and fat may differ in their ability to support energy-requiring physiologic processes, such as protein synthesis and growth. If so, varying the constituents of infant formula might be therapeutically advantageous.
OBJECTIVE
We tested the hypothesis that low-birth-weight infants fed a diet containing 65% of nonprotein energy as carbohydrate oxidize relatively more carbohydrate and relatively less protein than do infants fed an isoenergetic, isonitrogenous diet containing 35% of nonprotein energy as carbohydrate.
DESIGN
Sixty-two low-birth-weight infants weighing from 750 to 1600 g at birth were assigned randomly and blindly to receive 1 of 5 formulas that differed only in the quantity and quality of nonprotein energy. Formula containing 544 kJ x kg(-1) x d(-1) with either 50%, 35%, or 65% of nonprotein energy as carbohydrate was administered to control subjects, group 1, and group 2, respectively. Groups 3 and 4 received gross energy intakes of 648 kJ x kg(-1) x d(-1) with 35% and 65% of nonprotein energy as carbohydrate. Protein intake was targeted at 4 g x kg(-1) x d(-1). Substrate oxidation was estimated from biweekly, 6-h measurements of gas exchange and 24-h urinary nitrogen excretion.
RESULTS
Carbohydrate oxidation was positively (r = 0.71, P < 0.0001) and fat oxidation was negatively (r = -0.46, P < 0.001) correlated with carbohydrate intake. Protein oxidation was negatively correlated with carbohydrate oxidation (r = -0.42, P < 0.001). Fat oxidation was not correlated with protein oxidation. Protein oxidation was less in infants receiving 65% of nonprotein energy as carbohydrate than in groups receiving 35% nonprotein energy as carbohydrate.
CONCLUSION
These data support the hypothesis that energy supplied as carbohydrate is more effective than energy supplied as fat in sparing protein oxidation in enterally fed low-birth-weight infants.
连续测量新生儿每分钟通气量和气体代谢。
DOI：
10.1152/jappl.1981.50.5.1098
发表时间：
1981
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Schulze,K;Kairam,R;Stefanski,M;Sciacca,R;James,LS
通讯作者：
James,LS
人类随意喂养高脂肪和高碳水化合物饮食期间的营养平衡和能量消耗。
DOI：
10.1093/ajcn/55.5.934
发表时间：
1992
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Thomas,CD;Peters,JC;Reed,GW;Abumrad,NN;Sun,M;Hill,JO
通讯作者：
Hill,JO