Blood-brain barrier dysfunction and recovery after ischemic stroke.
Blood-brain barrier dysfunction and recovery after ischemic stroke.
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DOI：
10.1016/j.pneurobio.2017.10.001
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发表时间：
2018-04
影响因子：
6.7
通讯作者：
Shi Y
中科院分区：
文献类型：
--
作者：
Jiang X;Andjelkovic AV;Zhu L;Yang T;Bennett MVL;Chen J;Keep RF;Shi Y
血脑屏障(BBB)在调节血脑界面的液体、溶质和细胞的运输，维持中枢神经系统内稳态微环境方面起着至关重要的作用。在病理情况下，如缺血性中风，血脑屏障可能被破坏，随后血液成分渗入大脑，正常神经功能受损。本文综述了我们对缺血性卒中后血脑屏障功能障碍和恢复机制的最新认识进展。神经血管单位中的中枢神经系统细胞以及血源性外周细胞不断地调节血脑屏障，影响其在缺血性卒中后的破坏和修复。卒中危险因素和并存情况的参与使血脑屏障易于发生解剖学和功能改变，从而加重血脑屏障功能障碍，从而使神经血管损伤的发病机制进一步复杂化。重点介绍了脑缺血损伤后血脑屏障的长期结构和功能恢复过程。随着新的研究工具的发展，未来对血脑屏障的研究很可能揭示出保护血脑屏障和改善缺血性卒中患者预后的潜在治疗靶点。
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes and cells at the blood-brain interface and maintaining the homeostatic microenvironment of the CNS. Under pathological conditions, such as ischemic stroke, the BBB can be disrupted, followed by the extravasation of blood components into the brain and compromise of normal neuronal function. This article reviews recent advances in our knowledge of the mechanisms underlying BBB dysfunction and recovery after ischemic stroke. CNS cells in the neurovascular unit, as well as blood-borne peripheral cells constantly modulate the BBB and influence its breakdown and repair after ischemic stroke. The involvement of stroke risk factors and comorbid conditions further complicate the pathogenesis of neurovascular injury by predisposing the BBB to anatomical and functional changes that can exacerbate BBB dysfunction. Emphasis is also given to the process of long-term structural and functional restoration of the BBB after ischemic injury. With the development of novel research tools, future research on the BBB is likely to reveal promising potential therapeutic targets for protecting the BBB and improving patient outcome after ischemic stroke.
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影响因子：
5.3
作者：
Alkayed, NJ;Goto, S;Hurn, PD
通讯作者：
Hurn, PD
DOI：
10.1097/01.wcb.0000091762.61714.fe
发表时间：
2003-11-01
影响因子：
6.3
作者：
Andjelkovic, AV;Stamatovic, SM;Keep, RF
通讯作者：
Keep, RF
影响因子：
2.5
作者：
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通讯作者：
Iruela-Arispe, ML
影响因子：
6.2
作者：
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通讯作者：
Prat A
影响因子：
4.7
作者：
Aggarwal, Aanchal;Khera, Alka;Sandhir, Rajat
通讯作者：
Sandhir, Rajat