Statistical and agent-based modelling of the transmissibility of different SARS-CoV-2 variants in England and impact of different interventions.

Statistical and agent-based modelling of the transmissibility of different SARS-CoV-2 variants in England and impact of different interventions.
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基于统计和代理的建模英格兰不同SARS-COV-2变体的可传播性以及不同干预措施的影响。

DOI:
10.1098/rsta.2021.0315
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发表时间:
2022-10-03
影响因子:
5
通讯作者:
Kerr, C. C.
Kerr, C. C.
中科院分区:
综合性期刊2区
文献类型:
--
作者:
Panovska-Griffiths, J.;Swallow, B.;Hinch, R.;Cohen, J.;Rosenfeld, K.;Stuart, R. M.;Ferretti, L.;Di Lauro, F.;Wymant, C.;Izzo, A.;Waites, W.;Viner, R.;Bonell, C.;Fraser, C.;Klein, D.;Kerr, C. C.

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英国SARS-CoV-2疫情受到B.1.177、Alpha和Delta等新病毒变体的出现以及不断变化的限制的影响。我们在2021年6月使用统计模型和基于代理的模型Covasim估计B.1.177的传播性比野生型高20%,Alpha比B.1.177高50-80%,Delta比Alpha高65-90%。使用Covasim的这些估计值(校准日期为2020年9月1日至2021年6月20日),我们发现,由于Delta的高传播性,Delta变异导致的感染复发不会被阻止,但通过将限制放宽延迟一个月并继续接种疫苗,将大大减少。这篇文章是“模拟现实生活中的流行病的技术挑战和克服这些挑战的例子”主题的一部分。
The English SARS-CoV-2 epidemic has been affected by the emergence of new viral variants such as B.1.177, Alpha and Delta, and changing restrictions. We used statistical models and the agent-based model Covasim, in June 2021, to estimate B.1.177 to be 20% more transmissible than the wild type, Alpha to be 50–80% more transmissible than B.1.177 and Delta to be 65–90% more transmissible than Alpha. Using these estimates in Covasim (calibrated 1 September 2020 to 20 June 2021), in June 2021, we found that due to the high transmissibility of Delta, resurgence in infections driven by the Delta variant would not be prevented, but would be strongly reduced by delaying the relaxation of restrictions by one month and with continued vaccination. This article is part of the theme issue ‘Technical challenges of modelling real-life epidemics and examples of overcoming these’.
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