Neuronal and Non-neuronal Cell Types Displaying Circadian Rhythmicity in the Mammalian Suprachiasmatic Nucleus
Neuronal and Non-neuronal Cell Types Displaying Circadian Rhythmicity in the Mammalian Suprachiasmatic Nucleus
复制标题
哺乳动物视交叉上核中显示昼夜节律的神经元和非神经元细胞类型
DOI：
10.1007/s12264-020-00551-1
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发表时间：
2020-07
影响因子：
5.6
通讯作者：
Wang Han
中科院分区：
文献类型：
--
作者：
Tahajjul Taufique S K;Wang Han
昼夜节律的周期为*24小时，几乎在所有生物体中都有体现[1]。昼夜节律的分子遗传机制的发现是生物学史上最激动人心和鼓舞人心的篇章之一，并于2017年获得了诺贝尔生理学或医学奖[2]。同样令人兴奋和鼓舞的是下丘脑视交叉上核（SCN）参与协调昼夜节律活动的发现。哺乳动物的生理学、代谢和行为 [3]。长期以来，人们知道聚集在 SCN 中的不同细胞类型会产生深刻的复杂性 [3]。尽管存在细胞异质性，SCN 仍能够主要通过其神经元的内在连接性产生精确的输出，以使生物体与昼夜节律周期同步 [3]。此外，最近的研究表明星形胶质细胞等非神经元细胞对 SCN 中昼夜节律的产生有贡献[4].之前的组织范围转录组学研究已经确定了SCN中经典时钟基因和神经肽表达的时间变化[5]。然而，这些时间变化已在大量混合细胞类型中平均。因此，来自不同细胞类型的潜在输入尚未得到解决，因此细胞特异性信息和含义尚不清楚。单细胞RNA-seq（scRNA-seq）的最新进展促进了细胞的表征许多组织的概况，包括下丘脑和 SCN [6,7]。然而，对 SCN 的系统细胞网络和遗传特性的理解仍然难以捉摸。
Circadian rhythms have a period of *24 h and are manifested in almost all living organisms [1].The discovery of the molecular genetic mechanisms underlying circadian rhythmicity was one of the most exciting and inspiring chapters in the history of biology and won the Nobel Prize in Physiology or Medicine in 2017 [2].Equally exciting and inspiring was the discovery that the hypothalamic suprachiasmatic nucleus(SCN)is involved in orchestrating the daily rhythmic activity of physiology,metabolism,and behavior in mammals [3].Different cell types clustered in the SCN have long been known to generate profound complexity [3].Despite the cellular heterogeneity,the SCN is able to generate precise outputs primarily through the intrinsic connectivity of their neurons to synchronize the organism to a circadian cycle [3].In addition,recent studies have suggested a contribution of non-neuronal cells such as astrocytes to the generation of circadian rhythms in the SCN [4].Previous tissue-wide transcriptomic studies have already identified the temporal changes in the expression of canonical clock genes and neuropeptides in the SCN [5].However,these temporal changes have been averaged over a large population of mixed cell types.As a result,the potential inputs specifically from different cell types have not been resolved,and thus the cell-specific information and implications are not yet clear.Recent advances in single-cell RNA-seq(scRNA-seq)have facilitated the characterization of cellular profiles of many tissues,including the hypothalamus and SCN [6,7].However,an understanding of the systematic cellular network and genetic properties of the SCN remains elusive.
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单细胞转录分析揭示了中央昼夜节律涉及的新型神经元表型和相互作用网络。
影响因子：
4.3
作者：
Park J;Zhu H;O'Sullivan S;Ogunnaike BA;Weaver DR;Schwaber JS;Vadigepalli R
通讯作者：
Vadigepalli R
影响因子：
48
作者：
Angermueller C;Clark SJ;Lee HJ;Macaulay IC;Teng MJ;Hu TX;Krueger F;Smallwood S;Ponting CP;Voet T;Kelsey G;Stegle O;Reik W
通讯作者：
Reik W
影响因子：
25
作者：
Romanov RA;Zeisel A;Bakker J;Girach F;Hellysaz A;Tomer R;Alpár A;Mulder J;Clotman F;Keimpema E;Hsueh B;Crow AK;Martens H;Schwindling C;Calvigioni D;Bains JS;Máté Z;Szabó G;Yanagawa Y;Zhang MD;Rendeiro A;Farlik M;Uhlén M;Wulff P;Bock C;Broberger C;Deisseroth K;Hökfelt T;Linnarsson S;Horvath TL;Harkany T
通讯作者：
Harkany T
影响因子：
20.6
作者：
Wang H
通讯作者：
Wang H
影响因子：
16.2
作者：
Brancaccio M;Patton AP;Chesham JE;Maywood ES;Hastings MH
通讯作者：
Hastings MH