Epilepsy risk in offspring of affected parents; a cohort study of the "maternal effect" in epilepsy.
Epilepsy risk in offspring of affected parents; a cohort study of the "maternal effect" in epilepsy.
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DOI：
10.1002/acn3.51258
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发表时间：
2021-01
影响因子：
5.3
通讯作者：
Christensen J
中科院分区：
文献类型：
--
作者：
Dreier JW;Ellis CA;Berkovic SF;Cotsapas C;Ottman R;Christensen J
评估癫痫母亲的后代患癫痫的风险是否高于癫痫父亲的后代。在一项基于人群的前瞻性登记研究中，我们考虑了1981年至2016年期间出生在丹麦的所有单胎婴儿（N = 1，754，742）。从1977年以来的丹麦国家患者登记册，我们确定了所有研究参与者及其家庭成员的癫痫诊断。使用考克斯回归模型估计风险比（HR）和相应的95%置信区间（CI），并对相关混杂因素进行调整。我们纳入了1，754，742名参与超过3000万人年随访的个体。未患病父母的后代癫痫发病率为78.8（95% CI：77.8-79.8）/100，000人年，而父亲患病的后代的相应比率为172/100，000人年（95% CI：156-187），母亲患病的后代为260/100，000人年（95% CI：243-277）。与父亲患病相比，母亲患病与后代患癫痫的风险高出1.45倍（95%CI：1.30-1.63）。在雄性（HR = 1.39，95% CI：1.19-1.62）和雌性后代（HR = 1.53，95% CI：1.30-1.80）中均发现了这种母体效应，并且在后代发病时的不同年龄段均发现了这种母体效应。在家族性癫痫中也发现了母体效应（即患病的父母有一个患病的兄弟姐妹; HR = 1.50，95% CI：1.04−2.16）。在这项全国性的队列研究中，我们发现母亲对后代癫痫风险有明显的影响。
To assess whether the risk of epilepsy is higher in offspring of mothers with epilepsy than in offspring of fathers with epilepsy. In a prospective population‐based register study, we considered all singletons born in Denmark between 1981 and 2016 (N = 1,754,742). From the Danish National Patient Register since 1977, we identified epilepsy diagnoses in all study participants and their family members. Cox regression models were used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CI), adjusted for relevant confounders. We included 1,754,742 individuals contributing > 30 million person‐years of follow‐up. The incidence rate of epilepsy in offspring of unaffected parents was 78.8 (95% CI: 77.8–79.8) per 100,000 person‐years, while the corresponding rate in offspring with an affected father was 172 per 100,000 person‐years (95% CI: 156–187) and in offspring with an affected mother was 260 per 100,000 person‐years (95% CI: 243–277). Having an affected mother was associated with a 1.45‐fold (95% CI: 1.30–1.63) higher risk of epilepsy in the offspring, compared to having an affected father. This maternal effect was found both in male (HR = 1.39, 95% CI: 1.19–1.62) and female offspring (HR = 1.53, 95% CI: 1.30–1.80), and across various ages at onset in the offspring. The maternal effect was also found in familial epilepsies (i.e. where the affected parent had an affected sibling; HR = 1.50, 95% CI: 1.04−2.16). We found a clear maternal effect on offspring risk of epilepsy in this nationwide cohort study.
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影响因子：
5
作者：
OTTMAN, R;HAUSER, WA;SUSSER, M
通讯作者：
SUSSER, M
影响因子：
3.4
作者：
Mors, Ole;Perto, Gurli P.;Mortensen, Preben Bo
通讯作者：
Mortensen, Preben Bo
影响因子：
9.8
作者：
Greenberg, DA;Durner, M;Dicker, E
通讯作者：
Dicker, E
影响因子：
9.9
作者：
Afawi, Zaid;Oliver, Karen L.;Berkovic, Samuel F.
通讯作者：
Berkovic, Samuel F.
影响因子：
3
作者：
Cvetkovska, Emilija;Panov, Sasho;Kuzmanovski, Igor
通讯作者：
Kuzmanovski, Igor