Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study.
Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study.
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基于体表面积的肝脏体积估计是否适用于超重或肥胖儿童？体内验证研究。
DOI：
10.1111/cts.13059
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Shakhnovich V
中科院分区：
文献类型：
--
作者：
Hosey-Cojocari C;Chan SS;Friesen CS;Robinson A;Williams V;Swanson E;O'Toole D;Radford J;Mardis N;Johnson TN;Leeder JS;Shakhnovich V
肝脏是负责从体内清除大多数药物的主要器官，因此决定了随时间推移的全身药物浓度。肝脏的药物清除率似乎与器官大小直接相关。在儿童中，器官大小随着儿童年龄和生长而变化。在健康儿童和成人中，肝体积与体表面积（BSA）相关，并通过BSA函数估算。然而，这些关系来自“典型”人群，目前尚不清楚它们是否扩展到人群“离群值”的肝脏体积估计，例如超重或肥胖儿童，他们目前占儿科人群的三分之一。本研究使用计算机断层扫描或磁共振成像测量了99名正常体重、超重或肥胖儿童（2-21岁）的肝脏体积，并将器官测量值与使用已建立的肝脏体积方程计算的估计值进行了比较。先前开发的公式BSA与肝脏体积充分估计肝脏体积的儿童，无论体重状况。
The liver is the primary organ responsible for clearing most drugs from the body and thus determines systemic drug concentrations over time. Drug clearance by the liver appears to be directly related to organ size. In children, organ size changes as children age and grow. Liver volume has been correlated with body surface area (BSA) in healthy children and adults and has been estimated by functions of BSA. However, these relationships were derived from “typical” populations and it is unknown whether they extend to estimations of liver volumes for population “outliers,” such as children with overweight or obesity, who today represent one‐third of the pediatric population. Using computerized tomography or magnetic resonance imaging, this study measured liver volumes in 99 children (2–21 years) with normal weight, overweight, or obesity and compared organ measurements with estimates calculated using an established liver volume equation. A previously developed equation relating BSA to liver volume adequately estimates liver volumes in children, regardless of weight status.
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影响因子：
--
作者：
Du Bois, D;Du Bois, EF
通讯作者：
Du Bois, EF
DOI：
10.1001/jama.2014.732
发表时间：
2014-02-26
期刊：
JAMA
影响因子：
--
作者：
Ogden CL;Carroll MD;Kit BK;Flegal KM
通讯作者：
Flegal KM
影响因子：
4.5
作者：
Barter, Zoe E.;Tucker, Geoffrey T.;Rowland-Yeo, Karen
通讯作者：
Rowland-Yeo, Karen
DOI：
10.1080/152873901753215911
发表时间：
2001-11-23
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
影响因子：
--
作者：
Haddad, S;Restieri, C;Krishnan, K
通讯作者：
Krishnan, K
影响因子：
4.6
作者：
Johnson, TN;Tucker, GT;Rostami-Hodjegan, A
通讯作者：
Rostami-Hodjegan, A