Regulation of mitochondrial processes by protein S-nitrosylation.
Regulation of mitochondrial processes by protein S-nitrosylation.
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DOI：
10.1016/j.bbagen.2011.03.008
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发表时间：
2012-06
影响因子：
3
通讯作者：
Piantadosi, Claude A.
中科院分区：
文献类型：
--
作者：
Piantadosi, Claude A.
Nitric oxide (NO) exerts powerful physiological effects through guanylate cyclase (GC), a non-mitochondrial enzyme, and through the generation of protein cysteinyl-NO (SNO) adducts— a post-translational modification relevant to mitochondrial biology. A small number of SNO proteins, generated by various mechanisms, are characteristically found in mammalian mitochondria and influence the regulation of oxidative phosphorylation and other aspects of mitochondrial function. The principles by which mitochondrial SNO proteins are formed and their actions, independently or collectively with NO binding to heme, iron-sulfur centers, or to glutathione (GSH) are reviewed on a molecular background of SNO-based signal transduction. Mitochondrial SNO-proteins have been demonstrated to inhibit Complex I of the electron transport chain, to modulate mitochondrial reactive oxygen species (ROS) production, influence calcium-dependent opening of the mitochondrial permeability transition pore (MPTP), promote selective importation of mitochondrial protein, and stimulate mitochondrial fission. The ease of reversibility and the affirmation of regulated S-nitros(yl)ating and denitros(yl)ating enzymatic reactions supports hypotheses that SNO regulates the mitochondrion through redox mechanisms. SNO modification of mitochondrial proteins, whether homeostatic or adaptive (physiological), or pathogenic, is an area of active investigation. Mitochondrial SNO proteins are associated with mainly protective, bur soem pathological effects; the former mainly in inflammatory and ischemia/reperfusion syndromes and the latter in neurodegenerative diseases. Experimentally, mitochondrial SNO delivery is also emerging as a potential new area of therapeutics.
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影响因子：
3.5
作者：
Borutaite, V;Morkuniene, R;Brown, GC
通讯作者：
Brown, GC
影响因子：
3.9
作者：
ARNELLE, DR;STAMLER, JS
通讯作者：
STAMLER, JS
DOI：
10.1073/pnas.74.8.3203
发表时间：
1977-01-01
影响因子：
11.1
作者：
ARNOLD, WP;MITTAL, CK;MURAD, F
通讯作者：
MURAD, F
影响因子：
4.8
作者：
Beer, SM;Taylor, ER;Murphy, MP
通讯作者：
Murphy, MP
影响因子：
3.1
作者：
Brown, Guy C.
通讯作者：
Brown, Guy C.