Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans.
Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans.
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DOI：
10.1016/j.cell.2011.10.042
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发表时间：
2011-12-09
期刊：
影响因子：
64.5
通讯作者：
Hobert O
中科院分区：
文献类型：
--
作者：
Rechavi O;Minevich G;Hobert O
Induced expression of the Flock House virus in the soma of C. elegans results in the RNAi-dependent production of virus-derived, small interfering RNAs (viRNAs), which in turn silence the viral genome. We show here that the viRNA-mediated viral silencing effect is transmitted in a non-Mendelian manner to many ensuing generations. We show that the viral silencing agents, viRNAs, are transgenerationally transmitted in a template-independent manner and work in trans to silence viral genomes present in animals that are deficient in producing their own viRNAs. These results provide evidence for the transgenerational inheritance of an acquired trait, induced by the exposure of animals to a specific, biologically relevant physiological challenge. The ability to inherit such extragenic information may provide adaptive benefits to an animal.
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