Association of Hypomagnesemia and Liver Injury, Role of Gut-Barrier Dysfunction and Inflammation: Efficacy of Abstinence, and 2-Week Medical Management in Alcohol Use Disorder Patients.
Association of Hypomagnesemia and Liver Injury, Role of Gut-Barrier Dysfunction and Inflammation: Efficacy of Abstinence, and 2-Week Medical Management in Alcohol Use Disorder Patients.
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DOI：
10.3390/ijms231911332
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发表时间：
2022-09-26
影响因子：
5.6
通讯作者：
Vatsalya, Vatsalya
中科院分区：
文献类型：
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作者：
Winrich, Evan J.;Gala, Khushboo S.;Rajhans, Abhas;Rios-Perez, Christian D.;Royer, Amor J.;Zamani, Zarlakhta;Parthasarathy, Ranganathan;Marsano-Obando, Luis S.;Barve, Ashutosh J.;Schwandt, Melanie L.;Vatsalya, Vatsalya
（1）我们研究了血清镁水平在酒精使用障碍（AUD）患者的早期酒精性肝病（ALD）、肠道屏障功能障碍和炎症中的作用；最后，还研究了为期2周的戒酒和医疗处理对缓解低镁血症的效果。
（2）48名重度饮酒的AUD患者（34名男性/14名女性）参与了这项研究。根据血清丙氨酸氨基转移酶（ALT，一种肝损伤标志物）水平将患者分组，第1组（Group 1（Gr.1）；ALT≤40 U/L，7名男性/8名女性，无任何早期ALD迹象）和第2组（Group 2（Gr.2）；ALT>40 U/L，27名男性/6名女性，即早期ALD）。在每组内，这些患者又进一步分为镁水平正常（0.85 mmol/L及以上）和镁缺乏（低于0.85 mmol/L）的患者。所有参与者在基线（BL）时进行评估，并接受为期2周的标准医疗处理，在治疗结束时（2w）再次评估。
（3）本研究中的女性参与者基线镁水平显著低于男性参与者。第2组患者更倾向于肝细胞坏死型死亡，他们报告的慢性和近期重度饮酒量更高。治疗后第2组的镁水平提高到正常范围，尤其是在低镁血症亚组中（基线时为0.77±0.06 mmol/L，2周时为0.85±0.05 mmol/L，p = 0.02）。在第2组中，凋亡（K18M30）和坏死（K18M65）反应都与包含脂多糖结合蛋白（LBP）和肿瘤坏死因子-α（TNFα）的炎性体活性以及血清镁显著且独立相关。
（4）在有肝损伤的AUD患者中，为期2周的医疗处理似乎能将镁提高到正常水平。该组表现出炎症活性（LBP和TNFα），导致临床上显著的低镁血症。在该组中，镁水平以及独特的炎症活性似乎能显著预测肝细胞凋亡和坏死类型的死亡。
(1) We investigated the involvement of serum magnesium level in early alcoholic liver disease (ALD), gut barrier dysfunction, and inflammation in alcohol use disorder (AUD) patients; and lastly, the efficacy of 2-week abstinence and medical management to alleviate hypomagnesemia. (2) Forty-eight heavy drinking AUD patients (34 males (M)/14 females (F)) participated in this study. Patients were grouped by serum alanine aminotransferase (ALT) level (a marker of liver injury) as group 1 (Group 1 (Gr.1); ALT ≤ 40 U/L, 7M/8F, without any indication of early-stage ALD) and group 2 (Group 2 (Gr.2); ALT > 40 U/L, 27M/6F or early-stage ALD). These patients were sub-divided within each group into patients with normal magnesium (0.85 and more mmol/L) and deficient magnesium (less than 0.85 mmol/L) levels. All participants were assessed at baseline (BL) and received standard medical management for 2 weeks with reassessment at the treatment end (2w). (3) Female participants of this study showed a significantly lower baseline level of magnesium than their male counterparts. Gr.2 patients showed a greater propensity in the necrotic type of liver cell death, who reported higher chronic and recent heavy drinking. Magnesium level improved to the normal range in Gr.2 post-treatment, especially in the hypomagnesemia sub-group (0.77 ± 0.06 mmol/L (BL) vs. 0.85 ± 0.05 mmol/L (2w), p = 0.02). In Gr.2, both apoptotic (K18M30) and necrotic (K18M65) responses were significantly and independently associated with inflammasome activity comprising of LBP (Lipopolysaccharide binding-protein) and TNFα (Tumor necrosis factor -α), along with serum magnesium. (4) In AUD patients with liver injury, 2-week medical management seems to improve magnesium to a normal level. This group exhibited inflammatory activity (LBP and TNFα) contributing to clinically significant hypomagnesemia. In this group, the level of magnesium, along with the unique inflammatory activity, seems to significantly predict apoptotic and necrotic types of hepatocyte death.
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影响因子：
--
作者：
Umhau, John C.;Momenan, Reza;Heilig, Markus
通讯作者：
Heilig, Markus
DOI：
10.1097/01.alc.0000091227.26627.75
发表时间：
2003-10-01
影响因子：
3.2
作者：
Sobell, LC;Sobell, MB;Agrawal, S
通讯作者：
Agrawal, S
影响因子：
12.6
作者：
Shah, Neil D.;Ventura-Cots, Meritxell;Bataller, Ramon
通讯作者：
Bataller, Ramon
影响因子：
11.1
作者：
Aagaard, NK;Andersen, H;Dorup, I
通讯作者：
Dorup, I
DOI：
10.15288/jsa.1982.43.1157
发表时间：
1982-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
SKINNER, HA;SHEU, WJ
通讯作者：
SHEU, WJ