LBP rs2232618 polymorphism contributes to risk of sepsis after trauma.
LBP rs2232618 polymorphism contributes to risk of sepsis after trauma.
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LBP rs2232618 多态性增加创伤后败血症的风险
DOI：
10.1186/s13017-018-0214-1
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Jiang JX
中科院分区：
文献类型：
--
作者：
Lu HX;Sun JH;Wen DL;Du J;Zeng L;Zhang AQ;Jiang JX
背景研究发现LBP基因rs 2232618多态性（Phe 436 Leu）是一种功能性变异，与创伤患者脓毒症的易感性相关。我们的目的是通过扩大人口样本量，并进行荟萃分析，以确定更多的evidence.MethodsTraumatic患者从西南（n= 1296）和东南（n= 445）的中国参加了我们的研究。基因分型后，分析rs 2232618与脓毒症风险的关系。此外，我们进行了全面的文献检索和荟萃分析，以确定是否rs 2232618多态性赋予易感性sepsis.ResultsSignificance之间的相关性观察rs 2232618和败血症的风险在西南地区的患者（显性模型P= 0.002，隐性模型P= 0.006）。在东南队列（显性模型P= 0.005）和总体合并队列（显性和隐性模型P= 4.5 × 10−4，P= 0.041）中证实了这种关联。多因素Logistic回归分析显示，rs 2232618多态性与脓毒症的高风险相关（西南组OR = 1.77，95%CI = 1.26- 2.48，P = 0.001;东南组OR = 2.11，95%CI = 1.24- 3.58，P = 0.006;总队列OR = 1.54，95%CI = 1.34- 2.08，P = 0.006）。此外，对四项研究进行了荟萃分析（包括本研究）证实LBP中的rs 2232618增加了脓毒症的风险。显性模型OR = 1.75，P < 0.001，隐性模型OR = 6.08，P = 0.003;结论rs 2232618 T等位基因可显著增加脓毒症的发病风险。
BackgroundPrevious study revealed that rs2232618 polymorphism (Phe436Leu) within LBP gene is a functional variant and associated with susceptibility of sepsis in traumatic patients. Our aim was to confirm the reported association by enlarging the population sample size and perform a meta-analysis to find additional evidence.MethodsTraumatic patients from Southwest (n= 1296) and Southeast (n= 445) of China were enrolled in our study. After genotyping, the relationship between rs2232618 and the risk of sepsis was analyzed. Furthermore, we proceeded with a comprehensive literature search and meta-analysis to determine whether the rs2232618 polymorphism conferred susceptibility to sepsis.ResultsSignificance correlation was observed between rs2232618 and risk of sepsis in Southwest patients (P= 0.002 for the dominant model,P= 0.006 for the recessive model). The association was confirmed in Southeast cohort (P= 0.005 for the dominant model) and overall combined cohorts (P= 4.5 × 10−4,P= 0.041 for the dominant and recessive model). Multiple logistical regression analyses suggested that rs2232618 polymorphism was related to higher risk of sepsis (OR = 1.77, 95% CI = 1.26–2.48,P= 0.001 in Southwest patients; OR = 2.11, 95% CI = 1.24–3.58,P= 0.006 in Southeast cohort; OR = 1.54, 95% CI = 1.34–2.08,P= 0.006 in overall cohort). Furthermore, meta-analysis of four studies (including the present study) confirmed that rs2232618 within LBP increased the risk of sepsis (OR = 1.75,P< 0.001 for the dominant model; OR = 6.08,P= 0.003 for the recessive model; OR = 2.72,P< 0.001 for the allelic model).ConclusionsThe results from our replication study and meta-analysis provided firm evidence that rs2232618T allele significantly increased the risk of sepsis.
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影响因子：
2
作者：
Cunningham, Steven C;Malone, Debra L;Napolitano, Lena M
通讯作者：
Napolitano, Lena M
影响因子：
32.4
作者：
Eckert, Jana K.;Kim, Young J.;Schumann, Ralf R.
通讯作者：
Schumann, Ralf R.
DOI：
10.1084/jem.20111354
发表时间：
2011-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Xiao W;Mindrinos MN;Seok J;Cuschieri J;Cuenca AG;Gao H;Hayden DL;Hennessy L;Moore EE;Minei JP;Bankey PE;Johnson JL;Sperry J;Nathens AB;Billiar TR;West MA;Brownstein BH;Mason PH;Baker HV;Finnerty CC;Jeschke MG;López MC;Klein MB;Gamelli RL;Gibran NS;Arnoldo B;Xu W;Zhang Y;Calvano SE;McDonald-Smith GP;Schoenfeld DA;Storey JD;Cobb JP;Warren HS;Moldawer LL;Herndon DN;Lowry SF;Maier RV;Davis RW;Tompkins RG;Inflammation and Host Response to Injury Large-Scale Collaborative Research Program
通讯作者：
Inflammation and Host Response to Injury Large-Scale Collaborative Research Program
影响因子：
3.1
作者：
Bronkhorst, Maarten W. G. A.;Patka, Peter;Van Lieshout, Esther M. M.
通讯作者：
Van Lieshout, Esther M. M.
影响因子：
15.8
作者：
Cabrera CP;Manson J;Shepherd JM;Torrance HD;Watson D;Longhi MP;Hoti M;Patel MB;O'Dwyer M;Nourshargh S;Pennington DJ;Barnes MR;Brohi K
通讯作者：
Brohi K