Pregnancy cohorts and biobanking in sub-Saharan Africa: a systematic review.
Pregnancy cohorts and biobanking in sub-Saharan Africa: a systematic review.
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DOI：
10.1136/bmjgh-2020-003716
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发表时间：
2020-11
影响因子：
8.1
通讯作者：
PRECISE Network
中科院分区：
文献类型：
--
作者：
Bone JN;Pickerill K;Woo Kinshella ML;Vidler M;Craik R;Poston L;Stones W;Sevene E;Temmerman M;Koech Etyang A;Roca A;Russell D;Tribe RM;von Dadelszen P;Magee LA;PRECISE Network
技术进步和高通量生物检测可以促进从包括孕妇在内的人群队列中发现生物库中的科学。与健康结果相关的生物途径因地理位置不同而不同，高收入国家的数据可能不会概括到低资源环境。我们进行了一项系统的回顾，以确定撒哈拉以南非洲(SSA)的预期怀孕队列，其中包括具有增加发现科学机会的潜力的生物库样本。纳入标准是怀孕期间的前瞻性数据收集，以及与SSA相关的生物库。数据来源包括：科学数据库(具有全面的搜索词)、灰色文献、手工搜索适用的参考清单和专家输入。结果由两名独立评审员根据标题、摘要和全文分三个阶段进行筛选。这篇评论注册在Propero(CRD42019147483)上。14项SSA研究符合纳入标准，包括数据库搜索(n=8)、参考清单搜索(n=2)和专家输入(n=4)。有三项研究正在进行数据收集。人数最多的国家是南非和莫桑比克(南部非洲)(n=3)、贝宁(西非)(n=4)和坦桑尼亚(东非)(n=4)；包括估计31名 763名妇女。通常采集的样本包括血液、脐带血和胎盘。七项研究收集了新生儿样本。常见的临床结果包括孕产妇和围产儿死亡率、疟疾和早产。在南非，包括生物库在内的越来越多的怀孕队列正在产生一种独特的宝贵资源，用于协作发现科学，并增进对孕产妇、胎儿和新生儿发病率和死亡率的高区域风险的了解。未来的研究应该调整方案，并考虑它们的附加值和不同的贡献。
Technological advances and high throughput biological assays can facilitate discovery science in biobanks from population cohorts, including pregnant women. Biological pathways associated with health outcomes differ depending on geography, and high-income country data may not generalise to low-resource settings. We conducted a systematic review to identify prospective pregnancy cohorts in sub-Saharan Africa (SSA) that include biobanked samples with potential to enhance discovery science opportunity. Inclusion criteria were prospective data collection during pregnancy, with associated biobanking in SSA. Data sources included: scientific databases (with comprehensive search terms), grey literature, hand searching applicable reference lists and expert input. Results were screened in a three-stage process based on title, abstract and full text by two independent reviewers. The review is registered on PROSPERO (CRD42019147483). Fourteen SSA studies met the inclusion criteria from database searches (n=8), reference list searches (n=2) and expert input (n=4). Three studies have ongoing data collection. The most represented countries were South Africa and Mozambique (Southern Africa) (n=3), Benin (Western Africa) (n=4) and Tanzania (Eastern Africa) (n=4); including an estimated 31 763 women. Samples commonly collected were blood, cord blood and placenta. Seven studies collected neonatal samples. Common clinical outcomes included maternal and perinatal mortality, malaria and preterm birth. Increasingly numerous pregnancy cohorts in SSA that include biobanking are generating a uniquely valuable resource for collaborative discovery science, and improved understanding of the high regional risks of maternal, fetal and neonatal morbidity and mortality. Future studies should align protocols and consider their added value and distinct contributions.
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影响因子：
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作者：
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通讯作者：
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