Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection.
Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection.
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DOI：
10.4049/jimmunol.1200691
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发表时间：
2012-11-01
期刊：
影响因子：
--
通讯作者：
Artis D
中科院分区：
文献类型：
--
作者：
Giacomin PR;Siracusa MC;Walsh KP;Grencis RK;Kubo M;Comeau MR;Artis D
CD 4 + T辅助2型（TH 2）细胞因子反应促进过敏性炎症的发展，对寄生虫感染的免疫至关重要。最近的研究强调，嗜碱性粒细胞可以促进TH 2烟碱介导的炎症，并且在经典IL-3诱导的嗜碱性粒细胞与TSLP诱导的嗜碱性粒细胞之间存在表型和功能异质性。然而，是否不同的嗜碱性粒细胞群体发展后蠕虫感染，其相对贡献抗蠕虫免疫反应仍有待确定。旋毛虫感染小鼠后，我们发现嗜碱性细胞反应迅速诱导多个组织隔室，包括尿道引流淋巴结。旋毛虫诱导的嗜碱性粒细胞反应是IL-3-IL-3R非依赖性的，但严重依赖于TSLP-TSLPR相互作用。旋毛虫感染后嗜碱性粒细胞的选择性耗竭损害了感染诱导的CD 4 + TH 2细胞因子应答，表明TSLP依赖性嗜碱性粒细胞增强了蠕虫感染后的TH 2细胞因子应答。在蠕虫感染模型中TSLP依赖性嗜碱性粒细胞的鉴定和功能分类，以及它们最近描述的在促进特应性皮炎中的作用，表明这些细胞可能是在各种炎症或感染环境中促进TH 2烟碱相关炎症的关键群体。总的来说，这些数据表明，TSLP-嗜碱性粒细胞途径可能代表了一个新的目标，在设计的治疗干预策略，以促进或限制TH 2嘌呤依赖性免疫和炎症。
CD4+ T helper type 2 (TH2) cytokine responses promote the development of allergic inflammation and are critical for immunity to parasitic helminth infection. Recent studies highlighted that basophils can promote TH2 cytokine-mediated inflammation and that phenotypic and functional heterogeneity exists between classical IL-3-elicited basophils versus TSLP-elicited basophils. However, whether distinct basophil populations develop following helminth infection, and their relative contributions to anti-helminth immune responses remain to be defined. Following Trichinella spiralis infection of mice, we show that basophil responses are rapidly induced in multiple tissue compartments, including intestinal-draining lymph nodes. Trichinella-induced basophil responses were IL-3-IL-3R-independent but critically dependent on TSLP-TSLPR interactions. Selective depletion of basophils following Trichinella infection impaired infection-induced CD4+ TH2 cytokine responses, suggesting that TSLP-dependent basophils augment TH2 cytokine responses following helminth infection. The identification and functional classification of TSLP-dependent basophils in a helminth infection model, coupled with their recently-described role in promoting atopic dermatitis, suggests these cells may be a critical population in promoting TH2 cytokine-associated inflammation in a variety of inflammatory or infectious settings. Collectively, these data suggest that the TSLP-basophil pathway may represent a new target in the design of therapeutic intervention strategies to promote or limit TH2 cytokine-dependent immunity and inflammation.
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DOI：
10.1084/jem.20100734
发表时间：
2010-09-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Phythian-Adams AT;Cook PC;Lundie RJ;Jones LH;Smith KA;Barr TA;Hochweller K;Anderton SM;Hämmerling GJ;Maizels RM;MacDonald AS
通讯作者：
MacDonald AS
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.4049/jimmunol.0902447
发表时间：
2010-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kim S;Prout M;Ramshaw H;Lopez AF;LeGros G;Min B
通讯作者：
Min B
DOI：
10.1038/labinvest.2008.88
发表时间：
2008-11
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
通讯作者：
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DOI：
10.1084/jem.20091903
发表时间：
2009-09-28
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Maizels RM;Pearce EJ;Artis D;Yazdanbakhsh M;Wynn TA
通讯作者：
Wynn TA