Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.
Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.
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DOI：
10.4049/jimmunol.0902447
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发表时间：
2010-02-01
期刊：
影响因子：
--
通讯作者：
Min B
中科院分区：
文献类型：
--
作者：
Kim S;Prout M;Ramshaw H;Lopez AF;LeGros G;Min B
嗜碱性细胞通过其产生IL-4的能力被认为是免疫调节剂，IL-4是Th2免疫所需的关键细胞因子。最近也有报道称，在过敏原免疫后，嗜碱性粒细胞被短暂地募集到引流LN中，募集的嗜碱性粒细胞促进naïve CD4 T细胞向Th2效应细胞的分化。使用IL-3-/-和IL-3Rβ-/-小鼠，我们在这里报告了IL-3/IL-3R系统在蠕虫感染后将循环嗜碱性粒细胞招募到引流LN中是绝对需要的。出乎意料的是，IL-3或嗜碱性粒细胞LN募集的缺失在蠕虫诱导的Th2免疫应答中几乎没有作用。此外，感染小鼠的嗜碱性粒细胞减少并没有减少产生il -4的CD4 T细胞的发育。综上所述，我们的研究结果揭示了IL-3在将嗜碱性细胞募集到LN中的未知作用，并证明嗜碱性细胞在寄生虫感染期间不一定与Th2免疫的发展相关。
Basophils are recognized as immune modulators through their ability to produce IL-4, a key cytokine required for Th2 immunity. It has also recently been reported that basophils are transiently recruited into the draining LN after allergen immunization and that the recruited basophils promote the differentiation of naïve CD4 T cells into Th2 effector cells. Using IL-3-/- and IL-3Rβ-/- mice, we report here that the IL-3/IL-3R system is absolutely required to recruit circulating basophils into the draining LN following helminth infection. Unexpectedly, the absence of IL-3 or of basophil LN recruitment played little role in helminth-induced Th2 immune responses. Moreover, basophil depletion in infected mice did not diminish the development of IL-4-producing CD4 T cells. Taken together, our results reveal a previously unknown role of IL-3 in recruiting basophils to the LN and demonstrate that basophils are not necessarily associated with the development of Th2 immunity during parasite infection.
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