T Cell Protein Tyrosine Phosphatase in Osteoimmunology.
T Cell Protein Tyrosine Phosphatase in Osteoimmunology.
复制标题
骨免疫学中的T细胞蛋白酪氨酸磷酸酶
DOI：
10.3389/fimmu.2021.620333
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Wang YN;Liu S;Jia T;Feng Y;Zhang W;Xu X;Zhang D
骨免疫学强调骨骼和免疫细胞之间的双向交流。T细胞蛋白酪氨酸磷酸酶(TCPTP)，又称蛋白酪氨酸磷酸酶非受体2(PTPN2)，是一种细胞内蛋白酪氨酸磷酸酶(PTP)，通过去磷酸化靶蛋白来调节免疫反应和骨代谢。Tcptp基因敲除在全身性或特异性免疫细胞中可严重损害免疫功能，导致骨代谢紊乱。这篇综述为TCPTP在骨免疫学中的潜在作用提供了新的见解。总体而言，TCPTP对骨免疫学的调节是极其复杂的。TCPTP负性调节巨噬细胞活化和炎性因子分泌，抑制骨吸收。TCPTP调节T淋巴细胞分化和T淋巴细胞相关细胞因子信号转导，维持骨内环境的稳定。在一定的时间和条件下，TCPTP还有望通过靶向B淋巴细胞来调节骨代谢。本文就TCPTP在骨免疫学中的作用作一综述，该研究有望成为防治炎症性骨丢失的新靶点。
Osteoimmunology highlights the two-way communication between bone and immune cells. T cell protein tyrosine phosphatase (TCPTP), also known as protein-tyrosine phosphatase non-receptor 2 (PTPN2), is an intracellular protein tyrosine phosphatase (PTP) essential in regulating immune responses and bone metabolism via dephosphorylating target proteins. Tcptp knockout in systemic or specific immune cells can seriously damage the immune function, resulting in bone metabolism disorders. This review provided fresh insights into the potential role of TCPTP in osteoimmunology. Overall, the regulation of osteoimmunology by TCPTP is extremely complicated. TCPTP negatively regulates macrophages activation and inflammatory factors secretion to inhibit bone resorption. TCPTP regulates T lymphocytes differentiation and T lymphocytes-related cytokines signaling to maintain bone homeostasis. TCPTP is also expected to regulate bone metabolism by targeting B lymphocytes under certain time and conditions. This review offers a comprehensive update on the roles of TCPTP in osteoimmunology, which can be a promising target for the prevention and treatment of inflammatory bone loss.
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影响因子：
64.5
作者：
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