Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis.
Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis.
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幽门螺杆菌Caga Epiya基序和VACA基因型在东南亚国家胃肠道疾病发展的作用：一项荟萃分析。
DOI：
10.1186/1471-2334-12-223
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发表时间：
2012-09-21
影响因子：
3.7
通讯作者：
Yamaoka Y
中科院分区：
文献类型：
--
作者：
Sahara S;Sugimoto M;Vilaichone RK;Mahachai V;Miyajima H;Furuta T;Yamaoka Y
感染幽门螺杆菌的cagA阳性、cagA EPIYA基序ABD型以及vacA s1、m1和i1基因型菌株，与加剧的炎症反应以及胃十二指肠疾病风险增加相关。然而，目前尚不清楚东南亚地区幽门螺杆菌的流行情况和毒力因子基因型是否与西方国家相似。在此，我们对在东南亚发现的幽门螺杆菌菌株的cagA状态、cagA EPIYA基序流行情况以及vacA基因型进行了研究，并探讨了它们与胃十二指肠疾病的关联。
为确定幽门螺杆菌的cagA状态、cagA EPIYA基序和vacA基因型，我们对之前13篇报告进行了荟萃分析，这些报告涉及从多个东南亚国家检测到的1281株幽门螺杆菌。
在受检对象中，cagA阳性以及vacA s1、m1和i1基因型的频率分别为93%（1056/1133）、98%（1010/1033）、58%（581/1009）和96%（248/259）。分层分析显示，不同国家以及各国内不同种族之间，cagA状态和vacA基因型的频率存在显著差异。在感染东亚型菌株的患者中，越南北部和南部地区vacA m区基因型的频率差异显著（p < 0.001）。在所研究的东南亚人群中，感染vacA m1型或cagA阳性菌株与消化性溃疡疾病风险增加相关（优势比分别为1.46，95%置信区间：1.01 - 2.12，p = 0.046；以及2.83，95%置信区间：1.50 - 5.34，p = 0.001）。
在东南亚既发现了西方型也发现了东亚型幽门螺杆菌菌株，且以cagA阳性和vacA s1型为主。在东南亚，感染vacA m1型或cagA阳性菌株的患者患消化性溃疡疾病的风险增加。因此，检测该基因型以及cagA的存在可能具有临床实用价值。
Infection with cagA-positive, cagA EPIYA motif ABD type, and vacA s1, m1, and i1 genotype strains of Helicobacter pylori is associated with an exacerbated inflammatory response and increased risk of gastroduodenal diseases. However, it is unclear whether the prevalence and virulence factor genotypes found in Southeast Asia are similar to those in Western countries. Here, we examined the cagA status and prevalence of cagA EPIYA motifs and vacA genotypes among H. pylori strains found in Southeast Asia and examined their association with gastroduodenal disease. To determine the cagA status, cagA EPIYA motifs, and vacA genotypes of H. pylori, we conducted meta-analyses of 13 previous reports for 1,281 H. pylori strains detected from several Southeast Asian countries. The respective frequencies of cagA-positive and vacA s1, m1, and i1 genotypes among examined subjects were 93% (1,056/1,133), 98% (1,010/1,033), 58% (581/1,009), and 96% (248/259), respectively. Stratification showed significant variation in the frequencies of cagA status and vacA genotypes among countries and the individual races residing within each respective country. The frequency of the vacA m-region genotype in patients infected with East Asian-type strains differed significantly between the northern and southern areas of Vietnam (p < 0.001). Infection with vacA m1 type or cagA-positive strains was associated with an increased risk of peptic ulcer disease (odds ratio: 1.46, 95%CI: 1.01-2.12, p = 0.046 and 2.83, 1.50-5.34, p = 0.001, respectively) in the examined Southeast Asian populations. Both Western- and East Asian-type strains of H. pylori are found in Southeast Asia and are predominantly cagA-positive and vacA s1 type. In Southeast Asia, patients infected with vacA m1 type or cagA-positive strains have an increased risk of peptic ulcer disease. Thus, testing for this genotype and the presence of cagA may have clinical usefulness.
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影响因子：
4.8
作者：
Higashi, H;Yokoyama, K;Hatakeyama, M
通讯作者：
Hatakeyama, M
影响因子：
9.4
作者：
Bui Xuan Truong;Vo Thi Chi Mai;Azuma, Takeshi
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Azuma, Takeshi
影响因子：
2.4
作者：
Nguyen, Tung L.;Uchida, Tomohisa;Moriyama, Masatsugu
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Moriyama, Masatsugu
影响因子：
29.4
作者：
Atherton, JC;Peek, RM;Blaser, MJ
通讯作者：
Blaser, MJ
影响因子：
3.6
作者：
Backert, S;Moese, S;Meyer, TF
通讯作者：
Meyer, TF