S-glutathionylation in monocyte and macrophage (dys)function.
S-glutathionylation in monocyte and macrophage (dys)function.
复制标题
DOI：
10.3390/ijms140815212
复制
发表时间：
2013-07-24
影响因子：
5.6
通讯作者：
Asmis R
中科院分区：
文献类型：
--
作者：
Ullevig S;Kim HS;Asmis R
动脉粥样硬化是一种慢性炎症性疾病，涉及单核细胞和巨噬细胞在血管壁中的积聚。单核细胞和巨噬细胞在动脉粥样硬化病变的发生和发展中起着重要作用。当活性氧（ROS）压倒细胞抗氧化系统时发生的氧化应激有助于许多慢性炎症性疾病（包括动脉粥样硬化）的病理生理学。ROS的主要靶点是蛋白质中半胱氨酸残基上的反应性硫醇，其在氧化时可以改变细胞过程，包括信号传导途径、代谢途径、转录和翻译。蛋白质-S-谷胱甘肽化是谷胱甘肽（GSH）和蛋白质巯基之间形成混合二硫键的过程。直到最近，蛋白质-S-谷胱甘肽化与细胞氧化应激增加有关，但关键蛋白质靶点的S-谷胱甘肽化现在已成为生理学上重要的氧化还原信号传导机制，其在失调时有助于各种疾病过程。在这篇综述中，我们将探讨巯基氧化应激和蛋白-S-谷胱甘肽化在单核细胞和巨噬细胞功能障碍中的作用，作为与代谢紊乱相关的氧化应激和慢性炎症性疾病（包括动脉粥样硬化）之间的机制联系。
Atherosclerosis is a chronic inflammatory disease involving the accumulation of monocytes and macrophages in the vascular wall. Monocytes and macrophages play a central role in the initiation and progression of atherosclerotic lesion development. Oxidative stress, which occurs when reactive oxygen species (ROS) overwhelm cellular antioxidant systems, contributes to the pathophysiology of many chronic inflammatory diseases, including atherosclerosis. Major targets of ROS are reactive thiols on cysteine residues in proteins, which when oxidized can alter cellular processes, including signaling pathways, metabolic pathways, transcription, and translation. Protein-S-glutathionylation is the process of mixed disulfide formation between glutathione (GSH) and protein thiols. Until recently, protein-S-glutathionylation was associated with increased cellular oxidative stress, but S-glutathionylation of key protein targets has now emerged as a physiologically important redox signaling mechanism, which when dysregulated contributes to a variety of disease processes. In this review, we will explore the role of thiol oxidative stress and protein-S-glutathionylation in monocyte and macrophage dysfunction as a mechanistic link between oxidative stress associated with metabolic disorders and chronic inflammatory diseases, including atherosclerosis.
登录
查看更多内容
DOI：
10.1165/rcmb.2009-0136oc
发表时间：
2011-04-01
影响因子：
6.4
作者：
Aesif, Scott W.;Anathy, Vikas;Janssen-Heininger, Yvonne M. W.
通讯作者：
Janssen-Heininger, Yvonne M. W.
影响因子：
7.4
作者：
Asmis, Reto;Qiao, Mu;Asmis, Lars M.
通讯作者：
Asmis, Lars M.
DOI：
10.1111/j.1582-4934.2006.tb00407.x
发表时间：
2006-04
影响因子：
5.3
作者：
Dalle-Donne I;Aldini G;Carini M;Colombo R;Rossi R;Milzani A
通讯作者：
Milzani A
影响因子：
20.1
作者：
Chung HS;Wang SB;Venkatraman V;Murray CI;Van Eyk JE
通讯作者：
Van Eyk JE
影响因子：
3.8
作者：
Arefieva, TI;Kukhtina, NB;Krasnikova, TL
通讯作者：
Krasnikova, TL