Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia.
Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia.
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DOI：
10.1016/j.ijid.2014.09.003
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Albarrak AM
中科院分区：
文献类型：
--
作者：
Saad M;Omrani AS;Baig K;Bahloul A;Elzein F;Matin MA;Selim MA;Al Mutairi M;Al Nakhli D;Al Aidaroos AY;Al Sherbeeni N;Al-Khashan HI;Memish ZA;Albarrak AM
报告沙特阿拉伯一家中心的中东呼吸综合征冠状病毒（MERS-CoV）感染经验。对2012年10月1日至2014年5月31日发生的实验室确诊MERS CoV病例进行回顾性分析。信息来源包括医疗档案、感染控制爆发调查和MERS-CoV感染患者的预防医学数据库。收集了临床和流行病学方面的数据和结果。纳入了70例连续患者。患者大多年龄较大（中位年龄62岁），男性（46，65.7%），有医疗保健获得性感染（39，55.7%）。发热43例（61.4%），呼吸困难42例（60%），咳嗽38例（54.3%）。大多数发生肺炎（63，90%），需要重症监护（49，70%）。感染通常发生在集群中。需要重症监护的重度感染的独立风险因素包括合并感染（比值比（OR）14. 13，95%置信区间（CI）1. 58 - 126. 09; p = 0. 018）和低白蛋白（OR 6. 31，95% CI 1. 24 - 31. 90; p = 0. 026）。死亡率高（42，60%），年龄≥65岁与死亡率增加相关（OR 4.39，95% CI 2.13-9.05; p < 0.001）。MERS-CoV可引起需要重症监护的严重感染，死亡率高。发现合并感染和低白蛋白是严重感染的预测因子，而年龄≥65岁是死亡率增加的唯一预测因子。
To report the experience with Middle East respiratory syndrome coronavirus (MERS-CoV) infection at a single center in Saudi Arabia. Cases of laboratory-confirmed MERS-CoV occurring from October 1, 2012 to May 31, 2014 were reviewed retrospectively. Information sources included medical files, infection control outbreak investigations, and the preventive medicine database of MERS-CoV-infected patients. Data were collected on clinical and epidemiological aspects and outcomes. Seventy consecutive patients were included. Patients were mostly of older age (median 62 years), male (46, 65.7%), and had healthcare acquisition of infection (39, 55.7%). Fever (43, 61.4%), dyspnea (42, 60%), and cough (38, 54.3%) were the most common symptoms. The majority developed pneumonia (63, 90%) and required intensive care (49, 70%). Infection commonly occurred in clusters. Independent risk factors for severe infection requiring intensive care included concomitant infections (odds ratio (OR) 14.13, 95% confidence interval (CI) 1.58–126.09; p = 0.018) and low albumin (OR 6.31, 95% CI 1.24–31.90; p = 0.026). Mortality was high (42, 60%), and age ≥65 years was associated with increased mortality (OR 4.39, 95% CI 2.13–9.05; p < 0.001). MERS-CoV can cause severe infection requiring intensive care and has a high mortality. Concomitant infections and low albumin were found to be predictors of severe infection, while age ≥65 years was the only predictor of increased mortality.
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影响因子：
56.3
作者：
Cauchemez, Simon;Fraser, Christophe;Van Kerkhove, Maria D.;Donnelly, Christi A.;Riley, Steven;Rambaut, Andrew;Enouf, Vincent;van der Werf, Sylvie;Ferguson, Neil M.
通讯作者：
Ferguson, Neil M.
DOI：
10.1016/s0140-6736(13)60982-4
发表时间：
2013-06-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Guery B;Poissy J;el Mansouf L;Séjourné C;Ettahar N;Lemaire X;Vuotto F;Goffard A;Behillil S;Enouf V;Caro V;Mailles A;Che D;Manuguerra JC;Mathieu D;Fontanet A;van der Werf S;MERS-CoV study group
通讯作者：
MERS-CoV study group
影响因子：
4.9
作者：
Dyall, Julie;Coleman, Christopher M.;Frieman, Matthew B.
通讯作者：
Frieman, Matthew B.
影响因子：
19
作者：
Puzelli, S.;Azzi, A.;Donatelli, I.
通讯作者：
Donatelli, I.
DOI：
10.1056/nejmoa1306742
发表时间：
2013-08-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Assiri A;McGeer A;Perl TM;Price CS;Al Rabeeah AA;Cummings DA;Alabdullatif ZN;Assad M;Almulhim A;Makhdoom H;Madani H;Alhakeem R;Al-Tawfiq JA;Cotten M;Watson SJ;Kellam P;Zumla AI;Memish ZA;KSA MERS-CoV Investigation Team
通讯作者：
KSA MERS-CoV Investigation Team