Predictors of health-related quality of life in patients with colorectal cancer.
Predictors of health-related quality of life in patients with colorectal cancer.
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DOI：
10.1186/1477-7525-6-66
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发表时间：
2008-08-25
影响因子：
3.6
通讯作者：
West DW
中科院分区：
文献类型：
--
作者：
Yost KJ;Hahn EA;Zaslavsky AM;Ayanian JZ;West DW
大多数确定与结直肠癌患者健康相关生活质量（HRQL）相关变量的研究都是横断面研究或纳入其他诊断的患者。本研究的目的是确定结直肠癌患者HRQL的预测因素，并解释结果的临床重要性。我们进行了一项基于人群的纵向研究，通过加州癌症登记处的三个地区确定了患者。568名患者在诊断后大约9个月和19个月完成了调查。评估了来自癌症治疗功能评估-结直肠癌（FACT-C）的三个HRQL结果：社会/家庭幸福（SWB），情绪幸福（EWB）和试验结果指数（TOI），这是结直肠癌特异性的身体功能和幸福的总结测量。在多变量回归模型中评估社会人口统计学、癌症/健康和医疗保健变量。我们计算了预测变量的较大差异所对应的预测HRQL分数的差异，定义为区间变量的1个标准差差异或相对于名义变量的参考类别的差异。如果预测的评分差异至少与最小重要差异一样大，则解释变量对HRQL的影响被认为具有临床意义。更好的TOI、SWB和EWB的常见预测因子是更好的一般健康状况和与更好的癌症护理质量相关的因素。除了一般健康和感知护理质量外，预测变量仅用于SWB。已婚或以已婚方式生活与较好的幸福感相关，而男性或西班牙裔则与较差的幸福感相关。在评估的社会人口学、癌症/健康和保健变量中，只有西班牙裔对HRQL结果有临床意义的影响。我们的发现，特别是关于预测变量的临床重要性的信息，可以帮助临床医生识别可能存在未来HRQL不良风险的患者。潜在的可改变因素与癌症治疗的感知质量有关；因此，未来的研究应评估改善这些因素是否能改善HRQL。
Most studies that have identified variables associated with the health-related quality of life (HRQL) of patients with colorectal cancer have been cross-sectional or included patients with other diagnoses. The objectives of this study were to identify predictors of HRQL in patients with colorectal cancer and interpret the clinical importance of the results. We conducted a population-based longitudinal study of patients identified through three regions of the California Cancer Registry. Surveys were completed by 568 patients approximately 9 and 19 months post-diagnosis. Three HRQL outcomes from the Functional Assessment of Cancer Therapy – Colorectal (FACT-C) were evaluated: social/family well-being (SWB), emotional well-being (EWB) and the Trial Outcome Index (TOI), which is a colorectal cancer-specific summary measure of physical function and well-being. Sociodemographic, cancer/health, and healthcare variables were assessed in multivariable regression models. We computed the difference in predicted HRQL scores corresponding to a large difference in a predictor variable, defined as a 1 standard deviation difference for interval variables or the difference relative to the reference category for nominal variables. The effect of an explanatory variable on HRQL was considered clinically meaningful if the predicted score difference was at least as large as the minimally important difference. Common predictors of better TOI, SWB and EWB were better general health and factors related to better perceived quality of cancer care. Predictor variables in addition to general health and perceived quality of care were identified only for SWB. Being married/living as married was associated with better SWB, whereas being male or of Hispanic ethnicity was associated with worse SWB. Among the sociodemographic, cancer/health, and healthcare variables evaluated, only Hispanic ethnicity had a clinically meaningful effect on an HRQL outcome. Our findings, particularly the information on the clinical importance of predictor variables, can help clinicians identify patients who may be at risk for poor future HRQL. Potentially modifiable factors were related to perceived quality of cancer care; thus, future research should evaluate whether improving these factors improves HRQL.
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影响因子：
45.3
作者：
Hahn, EA;Glendenning, GA;Cella, D
通讯作者：
Cella, D
影响因子：
3.6
作者：
Parker, PA;Baile, WF;Cohen, L
通讯作者：
Cohen, L
影响因子：
6.2
作者：
GREENWALD, P
通讯作者：
GREENWALD, P
DOI：
10.1016/0021-9681(74)90017-4
发表时间：
1974-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
KAPLAN, MH;FEINSTEIN, AR
通讯作者：
FEINSTEIN, AR
影响因子：
120.7
作者：
Detmar, SB;Muller, MJ;Aaronson, NK
通讯作者：
Aaronson, NK