Optimizing relapse prevention and changing habits (REACH+) in anorexia nervosa.
Optimizing relapse prevention and changing habits (REACH+) in anorexia nervosa.
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优化神经性厌食症的复发预防和改变习惯（REACH+）。
DOI：
10.1002/eat.23724
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发表时间：
2022-06
影响因子：
5.5
通讯作者：
Thomas, J. Graham
中科院分区：
文献类型：
--
作者：
Steinglass, Joanna E.;Attia, Evelyn;Glasofer, Deborah R.;Wang, Yuanjia;Ruggiero, Julia;Walsh, B. Timothy;Thomas, J. Graham
神经性厌食症(AN)的复发率很高，即使在完全恢复体重后也是如此。这项研究旨在开发一种预防复发的治疗方法，专门针对持续性的适应不良行为(习惯)。复发预防和改变习惯(REACH+)旨在支持患者养成促进体重保持、鼓励健康和挑战使疾病永久化的习惯的习惯。临床试验设计使用多阶段优化策略(MOST)框架来有效地确定哪些治疗成分对积极结果有贡献。参与者将是60名在住院期间体重恢复的成人。治疗将包括6个月的门诊远程保健会议。REACH+包括行为、认知和动机组件，以及食物监测和技能巩固阶段。一个专门的在线平台延长了疗程之间的治疗时间。参与者将被随机分配到部分析因设计中每个组件的不同版本。结果将侧重于维持缓解，以体重减少率和试验结束状态衡量。有助于缓解的干预措施将被包括在优化的一揽子治疗方案中，适合在澳大利亚进行大规模预防复发的临床试验。
Relapse rates in anorexia nervosa (AN) are high, even after full weight restoration. This study aims to develop a relapse prevention treatment that specifically addresses persistent maladaptive behaviors (habits). Relapse Prevention and Changing Habits (REACH+) aims to support patients in developing routines that promote weight maintenance, encourage health, and challenge habits that perpetuate illness. The clinical trial design uses the Multiphase Optimization STrategy (MOST) framework to efficiently identify which components of treatment contribute to positive outcomes. Participants will be 60 adults with AN who have achieved weight restoration in an inpatient setting. Treatment will consist of 6 months of outpatient telehealth sessions. REACH+ consists of behavior, cognitive, and motivation components, as well as food monitoring and a skill consolidation phase. A specialized online platform extends therapy between sessions. Participants will be randomly assigned to different versions of each component in a fractional factorial design. Outcomes will focus on maintenance of remission, measured by rate of weight loss and end-of-trial status. Interventions that contribute to remission will be included in an optimized treatment package, suitable for a large-scale clinical trial of relapse prevention in AN.
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影响因子：
5.5
作者：
Neumayr, Christina;Voderholzer, Ulrich;Schlegl, Sandra
通讯作者：
Schlegl, Sandra
影响因子：
--
作者：
Schebendach, Janet E.;Mayer, Laurel E.;Walsh, B. Timothy
通讯作者：
Walsh, B. Timothy
影响因子：
158.5
作者：
Attia, Evelyn;Walsh, B. Timothy
通讯作者：
Walsh, B. Timothy
影响因子：
--
作者：
Halmi, KA;Agras, WS;Kraemer, HC
通讯作者：
Kraemer, HC
影响因子：
4.1
作者：
Foerde K;Walsh BT;Dalack M;Daw N;Shohamy D;Steinglass JE
通讯作者：
Steinglass JE