Comparison of percent density from raw and processed full-field digital mammography data.
Comparison of percent density from raw and processed full-field digital mammography data.
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DOI：
10.1186/bcr3372
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发表时间：
2013-01-04
期刊：
影响因子：
--
通讯作者：
Heine JJ
中科院分区：
文献类型：
--
作者：
Vachon CM;Fowler EE;Tiffenberg G;Scott CG;Pankratz VS;Sellers TA;Heine JJ
乳腺摄影密度已被确定为乳腺癌的一个强有力的风险因素，主要是使用数字化的电影乳房X线照片。全视野数字乳腺X射线摄影（FFDM）正在取代胶片乳腺X射线摄影，具有与胶片不同的属性，并提供原始和处理后的临床显示表示图像。我们评估并比较了FFDM原始和处理后的乳腺密度测量值及其与乳腺癌的相关性。对180例病例和180例对照进行了病例对照研究，这些病例和对照按年龄、绝经后激素使用和筛查史进行匹配。从General Electric Senographe 2000 D FFDM装置获得乳房X线照片。使用操作员辅助的积云法评估每个FFDM代表的密度百分比（PD）。使用Lin一致性相关系数（rc）评估图像类型内的再现性（n = 80）。使用连续测量的Pearson相关系数（r）和四分位数的加权kappa统计量（κ）评价图像表示（n = 360）之间的PD相关性。条件logistic回归用于估计两种图像表示的PD和乳腺癌相关性的比值比（OR），置信区间为95%。受试者工作特征曲线下面积（AUC）用于评估判别准确性。两种表示的百分比密度提供了相似的阅片员内重现性（原始图像rc= 0.92，处理图像rc= 0.87），并且相关（r = 0.82和κ = 0.64）。当控制体重指数时，PD的四分位数与乳腺癌和判别准确性的相关性对于原始（OR：1.0（参考），2.6（1.2至5.4），3.1（1.4至6.8），4.7（2.1至10.6）; AUC = 0.63）和处理后的表示（OR：1.0（参考），2.2（1.1至4.1）、2.2（1.1至4.4）、3.1（1.5至6.6）; AUC = 0.64）。使用操作员辅助方法从原始和处理后的FFDM图像测量的密度百分比具有重现性和相关性。这两种密度百分比测量方法都提供了与乳腺癌相似的关联。
Mammographic density has been established as a strong risk factor for breast cancer, primarily using digitized film mammograms. Full-field digital mammography (FFDM) is replacing film mammography, has different properties than film, and provides both raw and processed clinical display representation images. We evaluated and compared FFDM raw and processed breast density measures and their associations with breast cancer. A case-control study of 180 cases and 180 controls matched by age, postmenopausal hormone use, and screening history was conducted. Mammograms were acquired from a General Electric Senographe 2000D FFDM unit. Percent density (PD) was assessed for each FFDM representation using the operator-assisted Cumulus method. Reproducibility within image type (n = 80) was assessed using Lin's concordance correlation coefficient (rc). Correlation of PD between image representations (n = 360) was evaluated using Pearson's correlation coefficient (r) on the continuous measures and the weighted kappa statistic (κ) for quartiles. Conditional logistic regression was used to estimate odds ratios (ORs) for the PD and breast cancer associations for both image representations with 95% confidence intervals. The area under the receiver operating characteristic curve (AUC) was used to assess the discriminatory accuracy. Percent density from the two representations provided similar intra-reader reproducibility (rc= 0.92 for raw and rc= 0.87 for processed images) and was correlated (r = 0.82 and κ = 0.64). When controlling for body mass index, the associations of quartiles of PD with breast cancer and discriminatory accuracy were similar for the raw (OR: 1.0 (ref.), 2.6 (1.2 to 5.4), 3.1 (1.4 to 6.8), 4.7 (2.1 to 10.6); AUC = 0.63) and processed representations (OR: 1.0 (ref.), 2.2 (1.1 to 4.1), 2.2 (1.1 to 4.4), 3.1 (1.5 to 6.6); AUC = 0.64). Percent density measured with an operator-assisted method from raw and processed FFDM images is reproducible and correlated. Both percent density measures provide similar associations with breast cancer.
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影响因子：
3.8
作者：
Vedantham, S;Karellas, A;Hendrick, RE
通讯作者：
Hendrick, RE
DOI：
10.1093/jnci/91.16.1404
发表时间：
1999-08-18
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Boyd, NF;Lockwood, GA;Tritchler, DL
通讯作者：
Tritchler, DL
影响因子：
5.5
作者：
Mahesh, M
通讯作者：
Mahesh, M
影响因子：
19.7
作者：
HANLEY, JA;MCNEIL, BJ
通讯作者：
MCNEIL, BJ
影响因子：
3.8
作者：
Perez-Gomez, Beatriz;Ruiz, Franciso;Salas, Dolores
通讯作者：
Salas, Dolores