Nanomaterials toward the treatment of Alzheimer’s disease: Recent advances and future trends
Nanomaterials toward the treatment of Alzheimer’s disease: Recent advances and future trends
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纳米材料治疗阿尔茨海默病：最新进展和未来趋势
DOI：
10.1016/j.cclet.2021.01.014
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发表时间：
2021-01
影响因子：
9.1
通讯作者：
Zhang Yi
中科院分区：
文献类型：
--
作者：
Zeng Huihui;Qi Yujie;Zhang Zheyu;Liu Chuntai;Peng Weijun;Zhang Yi
阿尔茨海默病（AD）是一种进行性和致命的神经退行性疾病，是痴呆症的最常见原因。这种疾病的特征是进行性认知障碍。AD的患病率目前影响着超过3500万人，并且在全球范围内呈上升趋势。由于药物效力低和递送的许多各种障碍，目前没有有效的治疗方法。最近的纳米技术进步有可能提供有前途的治疗选择。纳米材料及其在生物医学中的应用越来越受到人们的关注，尤其是纳米材料作为药物载体的优势。本文旨在全面总结基于纳米材料的AD治疗策略的最新进展，包括纳米颗粒、脂质体和其他用于递送治疗化合物的选择以及用于细胞递送策略的支架。最后提出了今后的研究方向。我们希望这篇综述能为指导纳米材料在AD治疗中的未来发展提供重要信息。
Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative condition and the most prevalent cause of dementia. This disease is characterized by progressive cognitive impairment. The prevalence of AD is currently affecting more than 35 million people and is rising worldwide. No efficient therapy is currently available due to low drug potency and a number of various obstacles to delivery. Recent nanotechnological advancements have the potential to offer promising therapeutic options. Progress on nanomaterials as well as their applications in biomedicine is receiving increasing attention, especially the advantages of nanomaterial-based drug delivery systems. The aim of this review is to comprehensively summarize the latest developments in nanomaterial-based strategies for AD treatment, including nanoparticles, liposomes and other options for the delivery of therapeutic compounds and scaffolds for cell delivery strategies. Future research directions are also proposed. We hope this review can provide important information to guide the future development of nanomaterials in AD treatment.
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影响因子：
10.6
作者：
Wang, Feng;Ogasawara, Marcia A.;Huang, Peng
通讯作者：
Huang, Peng
DOI：
10.1016/j.apsb.2018.05.006
发表时间：
2018-10
期刊：
Acta pharmaceutica Sinica. B
影响因子：
--
作者：
Battogtokh G;Choi YS;Kang DS;Park SJ;Shim MS;Huh KM;Cho YY;Lee JY;Lee HS;Kang HC
通讯作者：
Kang HC
影响因子：
12.6
作者：
Du X;Wang X;Geng M
通讯作者：
Geng M
影响因子：
5.6
作者：
Xue-mei Gu;Han-Chang Huang;Zhao-feng Jiang
通讯作者：
Xue-mei Gu;Han-Chang Huang;Zhao-feng Jiang
影响因子：
8
作者：
Kong, Liang;Li, Xue-tao;Cheng, Lan
通讯作者：
Cheng, Lan