Small mitochondria-targeting molecules as anti-cancer agents.
Small mitochondria-targeting molecules as anti-cancer agents.
复制标题
DOI：
10.1016/j.mam.2009.12.003
复制
发表时间：
2010-02
影响因子：
10.6
通讯作者：
Huang, Peng
中科院分区：
文献类型：
--
作者：
Wang, Feng;Ogasawara, Marcia A.;Huang, Peng
关键词：
长期以来，人们在癌细胞中观察到线粒体结构和功能的变化。近年来，以线粒体为靶点的癌症治疗策略获得了势头。控制线粒体功能、细胞凋亡以及影响线粒体完整性和细胞活力的分子的信号通路是最近文献综述的重要主题。在本文中，我们首先简要总结了开发线粒体靶向化合物作为潜在抗癌药物的基本原理和生物学基础，然后提供了小分子直接影响线粒体或在功能上影响线粒体功能障碍的癌细胞代谢改变的关键例子。主要关注在癌症治疗中具有潜在应用的小分子化合物。我们还总结了关键的线粒体靶向化合物的药物开发阶段及其临床试验状态的信息。还讨论了靶向线粒体用于癌症治疗的优点和潜在的缺点。
Alterations in mitochondrial structure and functions have long been observed in cancer cells. Targeting mitochondria as a cancer therapeutic strategy has gained momentum in the recent years. The signaling pathways that govern mitochondrial function, apoptosis and molecules that affect mitochondrial integrity and cell viability have been important topics of the recent review in the literature. In this article, we first briefly summarize the rationale and biological basis for developing mitochondrial-targeted compounds as potential anticancer agents, and then provide key examples of small molecules that either directly impact mitochondria or functionally affect the metabolic alterations in cancer cells with mitochondrial dysfunction. The main focus is on the small molecular weight compounds with potential applications in cancer treatment. We also summarize information on the drug developmental stages of the key mitochondria-targeted compounds and their clinical trial status. The advantages and potential shortcomings of targeting the mitochondria for cancer treatment are also discussed.
登录
查看更多内容
DOI：
10.1101/sqb.1982.046.01.018
发表时间：
1981-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
CHEN, LB;SUMMERHAYES, IC;LAMPIDIS, TJ
通讯作者：
LAMPIDIS, TJ
影响因子：
56.9
作者：
BERNAL, SD;LAMPIDIS, TJ;CHEN, LB
通讯作者：
CHEN, LB
影响因子：
2.1
作者：
ARCADI, JA
通讯作者：
ARCADI, JA
影响因子：
3.3
作者：
BABBS, M;COLLIER, HOJ;TAYLOR, EP
通讯作者：
TAYLOR, EP
DOI：
10.1016/0006-291x(86)90032-x
发表时间：
1986-03-13
影响因子：
3.1
作者：
BODDEN, WL;PALAYOOR, ST;HAIT, WN
通讯作者：
HAIT, WN