An investigation into DNA methylation patterns associated with risk preference in older individuals.
An investigation into DNA methylation patterns associated with risk preference in older individuals.
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DOI：
10.1080/15592294.2021.1992910
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发表时间：
2022-10
期刊：
影响因子：
3.7
通讯作者：
McKnight, Amy Jayne
中科院分区：
文献类型：
--
作者：
Smyth, Laura J.;Cruise, Sharon M.;Tang, Jianjun;Young, Ian;McGuinness, Bernadette;Kee, Frank;McKnight, Amy Jayne
风险偏好是一种复杂的特征，受心理、社会、环境和遗传因素的影响。我们的目的是研究个体的风险偏好与他们的表观遗传特征之间的关系。风险偏好是通过要求北爱尔兰老龄化纵向研究队列的参与者在假设的收入情景中做出一系列选择来确定的。由此，衍生出四种风险偏好类别，从风险厌恶到风险寻求。Illumina的Infinium高密度甲基化检测用于评估862,927个CpGs的状态。获得了1,656人的风险偏好和DNA甲基化数据。在调整年龄、性别和外周白细胞计数的同时，评估了风险厌恶者和风险寻求者之间单位点DNA甲基化水平的分布。在这个发现队列中，当调整最大协变量数时，在风险厌恶者和风险寻求者之间鉴定出55个CpGs具有显著不同的甲基化水平（p≤x10−5）。协变量调整后，在全表观基因组关联水平上，任何风险偏好组的CpGs均未出现显著差异甲基化（p<9 × 10−8）。在所有分析中，蛋白质编码基因NWD1和LRP1是排名靠前的dmcpg所在的基因。这些基因的突变以前被认为与神经系统疾病有关。表观遗传修饰以前没有使用群体队列与风险厌恶联系起来，但可能代表了积累的重要生物标志物，复杂的决定因素。该研究的几个惊人结果支持进一步分析DNA甲基化是可测量生物标志物与健康行为之间的重要联系。
Risk preference is a complex trait governed by psycho-social, environmental and genetic determinants. We aimed to examine how an individual’s risk preference associates with their epigenetic profile. Risk preferences were ascertained by asking participants of the Northern Ireland COhort for the Longitudinal study of Ageing to make a series of choices between hypothetical income scenarios. From these, four risk preference categories were derived, ranging from risk-averse to risk-seeking. Illumina’s Infinium High-Density Methylation Assay was used to evaluate the status of 862,927 CpGs. Risk preference and DNA methylation data were obtained for 1,656 individuals. The distribution of single-site DNA methylation levels between risk-averse and risk-seeking individuals was assessed whilst adjusting for age, sex and peripheral white cell counts. In this discovery cohort, 55 CpGs were identified with significantly different levels of methylation (p≤x10−5) between risk-averse and risk-seeking individuals when adjusting for the maximum number of covariates. No CpGs were significantly differentially methylated in any of the risk preference groups at an epigenome-wide association level (p<9x10−8) following covariate adjustment. Protein-coding genes NWD1 and LRP1 were among the genes in which the top-ranked dmCpGs were located for all analyses conducted. Mutations in these genes have previously been linked to neurological conditions. Epigenetic modifications have not previously been linked to risk-aversion using a population cohort, but may represent important biomarkers of accumulated, complex determinants of this trait. Several striking results from this study support further analysis of DNA methylation as an important link between measurable biomarkers and health behaviours.
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影响因子：
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