Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.
Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.
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DOI：
10.1371/journal.pone.0249981
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Hetman M
中科院分区：
文献类型：
--
作者：
Slomnicki LP;Wei G;Burke DA;Hodges ER;Myers SA;Yarberry CD;Morehouse JR;Whittemore SR;Saraswat Ohri S;Hetman M
昼夜基因表达节律性驱动可能决定损伤反应的生理过程的昼夜振荡。虽然各种急性损伤的结果受到原始损伤发生时间的影响，但对脊髓损伤（SCI）后恢复的影响尚不清楚。我们报道，在ZT0（授时时间0，灯亮时间）和ZT12（灯灭时间）接受中度、T9挫伤性脊髓损伤的小鼠在损伤后6周的Basso小鼠量表（BMS）中显示出相似的后肢功能恢复。在一项独立研究中，ZT18与ZT6时脊髓损伤后BMS无显著差异。然而，梯子行走测试显示，损伤后第6周，ZT18小鼠的表现比ZT6小鼠略有改善。与这些对功能恢复的轻微影响相一致的是，终末组织学分析显示，损伤中心的白质保留没有显著差异。同样，在ZT6或ZT18损伤后1周分析时，血脊髓屏障破坏和神经炎症出现相似。因此，胸椎挫伤性脊髓损伤后的运动恢复不受神经损伤发生时间的实质性调节。
The circadian gene expression rhythmicity drives diurnal oscillations of physiological processes that may determine the injury response. While outcomes of various acute injuries are affected by the time of day at which the original insult occurred, such influences on recovery after spinal cord injury (SCI) are unknown. We report that mice receiving moderate, T9 contusive SCI at ZT0 (zeitgeber time 0, time of lights on) and ZT12 (time of lights off) showed similar hindlimb function recovery in the Basso mouse scale (BMS) over a 6 week post-injury period. In an independent study, no significant differences in BMS were observed after SCI at ZT18 vs. ZT6. However, the ladder walking test revealed modestly improved performance for ZT18 vs. ZT6 mice at week 6 after injury. Consistent with those minor effects on functional recovery, terminal histological analysis revealed no significant differences in white matter sparing at the injury epicenter. Likewise, blood-spinal cord barrier disruption and neuroinflammation appeared similar when analyzed at 1 week post injury at ZT6 or ZT18. Therefore, locomotor recovery after thoracic contusive SCI is not substantively modulated by the time of day at which the neurotrauma occurred.
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