Neural immune pathways and their connection to inflammatory diseases.
Neural immune pathways and their connection to inflammatory diseases.
复制标题
神经免疫途径及其与炎症性疾病的联系。
DOI：
10.1186/ar1002
复制
发表时间：
2003
影响因子：
4.9
通讯作者：
Sternberg, EM
中科院分区：
文献类型：
--
作者：
Eskandari, F;Webster, JI;Sternberg, EM
炎症和炎症反应是通过神经内分泌和免疫系统之间的双向通讯来调节的。许多研究已经建立了免疫系统和中枢神经系统 (CNS) 沟通的多种途径。中枢神经系统通过激素途径（包括下丘脑-垂体-肾上腺轴和神经内分泌应激反应的激素）以及神经元途径（包括自主神经系统）向免疫系统发出信号。下丘脑-垂体-性腺轴和性激素也具有重要的免疫调节作用。免疫系统通过可以穿过血脑屏障的免疫介质和细胞因子向中枢神经系统发出信号，或通过迷走神经或第二信使间接发出信号。免疫功能的神经内分泌调节对于应激或感染期间的生存以及调节炎症性疾病中的免疫反应至关重要。这篇综述讨论了神经免疫相互作用以及此类神经免疫调节炎症作用的证据，而不是讨论类风湿性关节炎中的单个炎症介质。
Inflammation and inflammatory responses are modulated by a bidirectional communication between the neuroendocrine and immune system. Many lines of research have established the numerous routes by which the immune system and the central nervous system (CNS) communicate. The CNS signals the immune system through hormonal pathways, including the hypothalamic–pituitary–adrenal axis and the hormones of the neuroendocrine stress response, and through neuronal pathways, including the autonomic nervous system. The hypothalamic–pituitary–gonadal axis and sex hormones also have an important immunoregulatory role. The immune system signals the CNS through immune mediators and cytokines that can cross the blood–brain barrier, or signal indirectly through the vagus nerve or second messengers. Neuroendocrine regulation of immune function is essential for survival during stress or infection and to modulate immune responses in inflammatory disease. This review discusses neuroimmune interactions and evidence for the role of such neural immune regulation of inflammation, rather than a discussion of the individual inflammatory mediators, in rheumatoid arthritis.
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影响因子：
2.9
作者：
BONAVERA, JJ;KALRA, SP;KALRA, PS
通讯作者：
KALRA, PS
影响因子：
2.7
作者：
Borovikova, LV;Ivanova, S;Tracey, KJ
通讯作者：
Tracey, KJ
影响因子：
5.9
作者：
AFFLECK, G;TENNEN, H;HIGGINS, P
通讯作者：
HIGGINS, P
影响因子：
56.9
作者：
BREDER, CD;DINARELLO, CA;SAPER, CB
通讯作者：
SAPER, CB
影响因子：
64.8
作者：
Borovikova, LV;Ivanova, S;Tracey, KJ
通讯作者：
Tracey, KJ