Adaptive evolution and functional redesign of core metabolic proteins in snakes.
Adaptive evolution and functional redesign of core metabolic proteins in snakes.
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DOI：
10.1371/journal.pone.0002201
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发表时间：
2008-05-21
期刊：
影响因子：
3.7
通讯作者：
Pollock DD
中科院分区：
文献类型：
--
作者：
Castoe TA;Jiang ZJ;Gu W;Wang ZO;Pollock DD
核心代谢蛋白的适应性进化事件是不常见的，甚至更罕见的是与重大的宏观进化转变。我们对蛇线粒体蛋白进行了广泛的分子进化分析，发现了多条证据，表明蛇有氧代谢核心的蛋白质经历了非常大的适应性变化的突发事件。我们发现，蛇线粒体蛋白质经历了前所未有的水平的积极选择，共同进化，收敛，并在功能关键的残基逆转。我们详细研究了细胞色素C氧化酶亚基I（COI），并表明它经历了广泛的修改，通常保守的残基参与质子运输和电子和氧的传递。因此，适应性变化可能改变了质子的流动和CO功能的其他方面，从而影响有氧代谢的基本特征。我们把这些过程称为“进化的重新设计”，因为情节爆发的幅度和它们影响核心功能残基的程度。蛇COI的进化重新设计与其他线粒体蛋白的适应性爆发和线粒体基因组结构的实质性变化相吻合。它通常也符合或之前的生态位的重大转变和广泛的生理适应肺减少，大型猎物消费和毒液进化有关的演变。这些重大进化事件的平行时间表明，代谢和线粒体功能的进化重新设计可能与蛇进化中观察到的生理和代谢效率、灵活性和创新的极端变化有关，或者是其基础。
Adaptive evolutionary episodes in core metabolic proteins are uncommon, and are even more rarely linked to major macroevolutionary shifts. We conducted extensive molecular evolutionary analyses on snake mitochondrial proteins and discovered multiple lines of evidence suggesting that the proteins at the core of aerobic metabolism in snakes have undergone remarkably large episodic bursts of adaptive change. We show that snake mitochondrial proteins experienced unprecedented levels of positive selection, coevolution, convergence, and reversion at functionally critical residues. We examined Cytochrome C oxidase subunit I (COI) in detail, and show that it experienced extensive modification of normally conserved residues involved in proton transport and delivery of electrons and oxygen. Thus, adaptive changes likely altered the flow of protons and other aspects of function in CO, thereby influencing fundamental characteristics of aerobic metabolism. We refer to these processes as “evolutionary redesign” because of the magnitude of the episodic bursts and the degree to which they affected core functional residues. The evolutionary redesign of snake COI coincided with adaptive bursts in other mitochondrial proteins and substantial changes in mitochondrial genome structure. It also generally coincided with or preceded major shifts in ecological niche and the evolution of extensive physiological adaptations related to lung reduction, large prey consumption, and venom evolution. The parallel timing of these major evolutionary events suggests that evolutionary redesign of metabolic and mitochondrial function may be related to, or underlie, the extreme changes in physiological and metabolic efficiency, flexibility, and innovation observed in snake evolution.
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影响因子：
3.9
作者：
Dong, S;Kumazawa, Y
通讯作者：
Kumazawa, Y
DOI：
10.1073/pnas.92.5.1604
发表时间：
1995-02-28
影响因子：
11.1
作者：
FETTER, JR;QIAN, J;FERGUSONMILLER, S
通讯作者：
FERGUSONMILLER, S
影响因子：
2.9
作者：
Qian, J;Mills, DA;Ferguson-Miller, S
通讯作者：
Ferguson-Miller, S
影响因子：
3.4
作者：
Jiang ZJ;Castoe TA;Austin CC;Burbrink FT;Herron MD;McGuire JA;Parkinson CL;Pollock DD
通讯作者：
Pollock DD
影响因子：
64.8
作者：
Fry, BG;Vidal, N;Kochva, E
通讯作者：
Kochva, E