Analysis of postembryonic heart development and maturation in the zebrafish, Danio rerio.
Analysis of postembryonic heart development and maturation in the zebrafish, Danio rerio.
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DOI：
10.1002/dvdy.23882
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发表时间：
2012-12
影响因子：
2.5
通讯作者：
Holtzman, Nathalia G.
中科院分区：
文献类型：
--
作者：
Singleman, Corinna;Holtzman, Nathalia G.
关键词：
心脏成熟对于动物的生存至关重要，并且必须在动物的整个生命中发生。斑马鱼越来越多地用于心脏病模型;然而，人们对心血管系统如何成熟知之甚少。我们进行了系统的分析，从幼虫到成年的心脏成熟和评估心脏功能的遗传和环境因素的影响。我们确定了心脏成熟的一个新步骤，称为心脏旋转，其中幼虫心脏旋转到胸腔内的最终方向，心房位于心室后面。这种旋转之后是心室的线性生长和球动脉与心室之间的角度增加。心室从矩形过渡到三角形，最后是一个明显被心房包围的圆形。此外，斑马鱼和人类的小梁图案相似，既有肌肉指状突起，又有跨越心腔的肌带。有趣的是，部分损失的心房收缩肌球蛋白重链6（myh 6/weahu 423/+）突变体的结果在成人保持幼虫的心脏形式。这些发现为研究遗传和环境因素对心血管发育的影响奠定了基础。
Cardiac maturation is vital for animal survival and must occur throughout the animal’s life. Zebrafish are increasingly used to model cardiac disease; however, little is known about how the cardiovascular system matures. We conducted a systematic analysis of cardiac maturation from larvae though to adulthood and assessed cardiac features influenced by genetic and environmental factors. We identified a novel step in cardiac maturation, termed cardiac rotation, where the larval heart rotates into its final orientation within the thoracic cavity with the atrium placed behind the ventricle. This rotation is followed by linear ventricle growth and an increase in the angle between bulbous arteriosus and the ventricle. The ventricle transitions from a rectangle, to a triangle and ultimately a circle that is significantly enveloped by the atrium. In addition, trabeculae are similarly patterned in the zebrafish and humans with both muscular fingerlike projections and muscle bands that span the cardiac chamber. Interestingly, partial loss of atrial contraction in myosin heavy chain 6 (myh6/weahu423/+) mutants result in the adult maintaining a larval cardiac form. These findings serve as a foundation for the study of defects in cardiovascular development from both genetic and environmental factors.
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影响因子：
20.1
作者：
Ding Y;Sun X;Huang W;Hoage T;Redfield M;Kushwaha S;Sivasubbu S;Lin X;Ekker S;Xu X
通讯作者：
Xu X
DOI：
10.1073/pnas.1019031108
发表时间：
2011-04-26
影响因子：
11.1
作者：
Hicken, Corinne E.;Linbo, Tiffany L.;Incardona, John P.
通讯作者：
Incardona, John P.
影响因子：
3.8
作者：
Antkiewicz, Dagmara S.;Peterson, Richard E.;Heideman, Warren
通讯作者：
Heideman, Warren
DOI：
10.1073/pnas.0900470106
发表时间：
2009-06-16
影响因子：
11.1
作者：
Koide, Tetsuya;Miyasaka, Nobuhiko;Yoshihara, Yoshihiro
通讯作者：
Yoshihara, Yoshihiro
影响因子：
3.4
作者：
Di Donato, Marisa;Dabic, Petar;Menicanti, Lorenzo
通讯作者：
Menicanti, Lorenzo