Protection of mice from Mycobacterium tuberculosis by ID87/GLA-SE, a novel tuberculosis subunit vaccine candidate.
Protection of mice from Mycobacterium tuberculosis by ID87/GLA-SE, a novel tuberculosis subunit vaccine candidate.
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DOI：
10.1016/j.vaccine.2011.07.094
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发表时间：
2011-10-13
期刊：
影响因子：
5.5
通讯作者：
Reed, Steven G.
中科院分区：
文献类型：
--
作者：
Windish, Hillarie Plessner;Duthie, Malcolm S.;Ireton, Greg;Lucas, Elyse;Laurance, John D.;Bailor, Remy H.;Coler, Rhea N.;Reed, Steven G.
结核病是一个主要的健康问题。非活体结核病(TB)候选疫苗不仅可能比目前的卡介苗(BCG)更安全，而且还可以用来增强卡介苗以增强或延长保护。然而，目前还没有针对结核病的亚单位疫苗。为了弥补这一差距并改善全球结核病状况，我们通过将3种有效的Mtb蛋白抗原Rv2875、Rv3478和Rv1886的基因从基因上融合到单一产品ID87中，产生了一种明确的亚单位疫苗。当给予基于TLR4激动剂的佐剂GLA-SE时，ID87免疫降低了实验感染小鼠肺部的结核分枝杆菌负担。ID87/GLA-SE免疫小鼠的细菌负荷减少的同时，在感染过程中，白细胞早期和显著地渗入肺部。ID87/GLA-SE似乎是一种有希望的新候选疫苗，值得进一步开发。
Tuberculosis is a major health concern. Non-living tuberculosis (TB) vaccine candidates may not only be safer than the current vaccine (BCG) but could also be used to boost BCG to enhance or elongate protection. No subunit vaccines, however, are currently available for TB. To address this gap and to improve the global TB situation, we have generated a defined subunit vaccine by genetically fusing the genes of 3 potent protein Mtb antigens, Rv2875, Rv3478 and Rv1886, into a single product: ID87. When delivered with a TLR4 agonist-based adjuvant, GLA-SE, ID87 immunization reduced Mtb burden in the lungs of experimentally-infected mice. The reduction in bacterial burden of ID87/GLA-SE immunized mice was accompanied by an early and significant leukocyte infiltration into the lungs during the infectious process. ID87/GLA-SE appears to be a promising new vaccine candidate that warrants further development.
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影响因子：
3.1
作者：
Ladel, CH;Blum, C;Kaufmann, SHE
通讯作者：
Kaufmann, SHE
DOI：
10.4161/hv.8570
发表时间：
2009-07-01
期刊：
HUMAN VACCINES
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通讯作者：
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影响因子：
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作者：
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