In vitro and preliminary in vivo validation of echo particle image velocimetry in carotid vascular imaging.
In vitro and preliminary in vivo validation of echo particle image velocimetry in carotid vascular imaging.
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DOI：
10.1016/j.ultrasmedbio.2010.11.017
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发表时间：
2011-03
影响因子：
2.9
通讯作者：
Shandas, Robin
中科院分区：
文献类型：
--
作者：
Zhang, Fuxing;Lanning, Craig;Mazzaro, Luciano;Barker, Alex J.;Gates, Phillip E.;Strain, W. David;Fulford, Jonathan;Gosling, Oliver E.;Shore, Angela C.;Bellenger, Nick G.;Rech, Bryan;Chen, Jiusheng;Chen, James;Shandas, Robin
关键词：
无创、易用、准确的人体血管壁切应力(WSS)测量在临床应用中一直具有挑战性。回声粒子图像测速仪(Echo PIV)在临床测量局部血流动力学和室壁剪切率方面显示出良好的前景。然而，到目前为止，该方法只在简单的流动条件下进行了验证。在这项研究中，我们在体外和体内条件下验证了Echo PIV。为了进行体外验证，我们使用了一个解剖学上正确的、符合要求的脉动流条件下的颈动脉分叉血流体模，并使用光学粒子图像测速仪(光学PIV)作为参考标准。为了在体内验证，我们比较了5名正常人颈动脉分叉处Echo PIV获得的二维速度场与在相同位置获得的相位对比MRI得出的速度测量结果。在这两项研究中，检测颈总动脉(CCA)、颈动脉分叉和颈内动脉远端(ICA)的二维二维两分量速度矢量、峰/中线速度、血流速度和壁剪切率(WSR)波形。用线性回归、相关分析和Bland-Altman分析对两种技术测量的不同波形的一致性进行量化。体外实验结果显示，Echo PIV在心动周期内产生了良好的时间相关速度矢量图图像，具有良好的时间(高达0.7毫秒)和空间(~0.5 mm)分辨率和质量，与光学PIV结果相当。此外，在速度和WSR测量方面，Echo PIV和光学PIV结果之间有很好的一致性。活体结果也显示，Echo PIV的速度与PC-MRI的速度很好地吻合。我们认为，Echo PIV可提供准确的颈动脉分叉部速度矢量和WSR测量，并可作为临床心血管血流动力学评估的重要工具。
Non-invasive, easy-to-use and accurate measurements of wall shear stress (WSS) in human blood vessels have always been challenging in clinical applications. Echo particle image velocimetry (Echo PIV) has shown promise for clinical measurements of local hemodynamics and wall shear rate. So far, however, the method has only been validated under simple flow conditions. In this study, we validated Echo PIV under in-vitro and in-vivo conditions. For in-vitro validation, we used an anatomically-correct, compliant carotid bifurcation flow phantom with pulsatile flow conditions, using optical particle image velocimetry (optical PIV) as the reference standard. For in-vivo validation, we compared Echo PIV-derived two dimensional velocity fields obtained at the carotid bifurcation in 5 normal subjects against phase-contrast MRI-derived velocity measurements obtained at the same locations. For both studies, time-dependent, two-dimensional two-component velocity vectors, peak/centerline velocity, flow rate and wall shear rate (WSR) waveforms at the common carotid artery (CCA), carotid bifurcation and distal internal carotid artery (ICA) were examined. Linear regression, correlation analysis and Bland-Altman analysis were used to quantify the agreement of different waveforms measured by the two techniques. In-vitro results showed that Echo PIV produced good images of time-dependent velocity vector maps over the cardiac cycle with excellent temporal (up to 0.7 msec) and spatial (~0.5 mm) resolutions and quality, on par with optical PIV results. Further, good agreement was found between Echo PIV and optical PIV results for velocity and WSR measurements. In-vivo results also showed good agreement between Echo PIV velocities and PC-MRI velocities. We conclude that Echo PIV provides accurate velocity vector and WSR measurements in the carotid bifurcation and has significant potential as a clinical tool for cardiovascular hemodynamics evaluation.
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DOI：
10.1243/09544119jeim572
发表时间：
2010-01-01
影响因子：
1.8
作者：
Hoskins, P. R.
通讯作者：
Hoskins, P. R.
影响因子：
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作者：
Liu, Lingli;Zheng, Hairong;Shandas, Robin
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DOI：
10.1115/1.2895545
发表时间：
1993-11-01
影响因子：
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作者：
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通讯作者：
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影响因子：
2.4
作者：
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影响因子：
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作者：
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