Cancer diagnosis in Catalonia (Spain) after two years of COVID-19 pandemic: an incomplete recovery.
Cancer diagnosis in Catalonia (Spain) after two years of COVID-19 pandemic: an incomplete recovery.
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DOI：
10.1016/j.esmoop.2022.100486
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发表时间：
2022-06
期刊：
影响因子：
7.3
通讯作者：
Borras, J. M.
中科院分区：
文献类型：
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作者：
Ribes, J.;Pareja, L.;Sanz, X.;Mosteiro, S.;Escriba, J. M.;Esteban, L.;Galvez, J.;Osca, G.;Rodenas, P.;Perez-Sust, P.;Borras, J. M.
这项研究旨在估计加泰罗尼亚COVID-19大流行前两年潜在未检测到的癌症。根据性别、年龄和肿瘤部位，在加泰罗尼亚病理学登记处（CPR）中比较了大流行前（2019年）和大流行期间（2020年3月至2022年1月）的癌症发病率。还通过皮尔逊相关系数（R）评估了癌症诊断与COVID-19医疗保健工作量之间的相关性。通过将2019年CPR癌症发病率（按性别和5岁年龄组）应用于2020年和2021年加泰罗尼亚人口金字塔，估计了大流行期间的预期癌症发病率（E）。认为观察到CPR事件癌症（O）。使用O/E比计算标准化发生率比（SIR）和95%置信区间（CI）。在两个大流行年后，癌症诊断减少了12%（SIR 0.88，95%CI 0.87-0.89），或107700未检测到的癌症（13000非黑色素瘤皮肤癌）。在没有非黑色素瘤皮肤癌的情况下，72%的癌症诊断不足是在2020年产生的。男性（整个大流行期间为−14%; 2020年为−21%; 2021年为−8%）的确诊率下降幅度大于女性（分别为− 9%、− 19%、− 3%），在除第五波（第一波为− 37%、第二波为− 16%、第三波为− 8%、第四波为− 6%、第五波为− 2%、第六波为−6%）以外的所有大流行波中以及所有成年年龄组中均出现了显著下降。在第一波中，CPR癌症诊断与初级保健的COVID-19病例数（R-0.91，95% CI-0.97至-0.75）以及传统医院病房（R-0.91，95% CI-0.99至-0.48）和重症监护（R-0.91，95% CI-0.98至-0.70）的入住率呈负相关。我们的研究大规模评估了大流行对癌症诊断的整体影响，并将选择偏差降至最低，结果显示，截至2022年2月，加泰罗尼亚的癌症检测尚未恢复到大流行前的水平。在等待基于人群的癌症登记处的癌症发病率数据时，早期CPR数据可以为西班牙癌症控制计划的制定提供信息。在加泰罗尼亚，病理性癌症诊断在两个大流行年份下降了12%。加泰罗尼亚可能仍有7700人（13000人包括非黑色素瘤皮肤癌）未被发现的癌症。来自基于人群的癌症登记处的待定数据、真实的实时病理学数据可以评估国家癌症控制计划。
This study aimed to estimate potential undetected cancers over the first 2 years of the COVID-19 pandemic in Catalonia. Cancer incidence was compared between pre-pandemic (2019) and pandemic (March 2020-January 2022) periods in the Catalan Pathology Registry (CPR) according to sex, age, and tumor site. The correlation between cancer diagnosis and COVID-19 health care workload was also evaluated by means of the Pearson's correlation coefficient (R). The expected incident cancers (E) during the pandemic were estimated by applying 2019 CPR cancer incidence specific rates by sex and 5-year age groups to the 2020 and 2021 Catalan population pyramids. CPR incident cancers were considered observed (O). Standardized incidence ratios (SIR) and 95% confidence intervals (CIs) were calculated using the O/E ratio. After two pandemic years, cancer diagnosis decreased by 12% (SIR 0.88, 95% CI 0.87-0.89), or ∼7700 undetected cancers (13 000 with nonmelanoma skin cancer). Without nonmelanoma skin cancer, 72% of the cancer underdiagnosis was generated in 2020. Diagnoses decreased more in men (whole pandemic −14%; 2020 −21%; 2021 −8%) than in women (−9%, −19%, −3%, respectively), dropping significantly overall in all pandemic waves but the fifth (first −37%, second −16%, third −8%, fourth −6%, fifth −2%, sixth −6%), and across all adult age groups. In the first wave, CPR cancer diagnosis was inversely correlated with COVID-19 caseload in primary care (R −0.91, 95% CI −0.97 to −0.75) and occupancy in conventional hospital wards (R −0.91, 95% CI −0.99 to −0.48) and intensive care (R −0.91, 95% CI 95% −0.98 to −0.70). Our study evaluated the overall pandemic impact on cancer diagnosis on a large scale and with minimal selection bias, showing that as of February 2022, cancer detection in Catalonia had not yet recovered to pre-pandemic levels. Pending cancer incidence data from population-based cancer registries, early CPR data could inform the development of Spanish cancer control plans. Pathological cancer diagnoses fell by 12% over the two pandemic years in Catalonia. There may still be 7700 individuals (13 000 including nonmelanoma skin cancer) undetected cancers in Catalonia. Pending data from population-based cancer registries, real time pathology data can assess national cancer control plans.
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DOI：
10.1093/bjs/znab426
发表时间：
2022-02-01
期刊：
The British journal of surgery
影响因子：
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作者：
Gathani T;Reeves G;Dodwell D;Horgan K;Kearins O;Kan SW;Sweetland S
通讯作者：
Sweetland S
共同-19大流行对西班牙癌症患者的护理的影响。
影响因子：
7.3
作者：
Amador M;Matias-Guiu X;Sancho-Pardo G;Contreras Martinez J;de la Torre-Montero JC;Peñuelas Saiz A;Garrido P;García-Sanz R;Rodríguez-Lescure Á;Paz-Ares L
通讯作者：
Paz-Ares L
DOI：
10.1016/j.lanepe.2021.100188
发表时间：
2021-10
期刊：
The Lancet regional health. Europe
影响因子：
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作者：
Erdmann F;Wellbrock M;Trübenbach C;Spix C;Schrappe M;Schüz J;Grabow D;Eichinger M
通讯作者：
Eichinger M
影响因子：
7.7
作者：
Achilleos S;Quattrocchi A;Gabel J;Heraclides A;Kolokotroni O;Constantinou C;Pagola Ugarte M;Nicolaou N;Rodriguez-Llanes JM;Bennett CM;Bogatyreva E;Schernhammer E;Zimmermann C;Costa AJL;Lobato JCP;Fernandes NM;Semedo-Aguiar AP;Jaramillo Ramirez GI;Martin Garzon OD;Mortensen LH;Critchley JA;Goldsmith LP;Denissov G;Rüütel K;Le Meur N;Kandelaki L;Tsiklauri S;O'Donnell J;Oza A;Kaufman Z;Zucker I;Ambrosio G;Stracci F;Hagen TP;Erzen I;Klepac P;Arcos González P;Fernández Camporro Á;Burström B;Pidmurniak N;Verstiuk O;Huang Q;Mehta NK;Polemitis A;Charalambous A;Demetriou CA
通讯作者：
Demetriou CA
DOI：
10.1056/nejmoa2114255
发表时间：
2021-10-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bar-On YM;Goldberg Y;Mandel M;Bodenheimer O;Freedman L;Kalkstein N;Mizrahi B;Alroy-Preis S;Ash N;Milo R;Huppert A
通讯作者：
Huppert A