Regulation of monoamine transporters: Role of transporter phosphorylation.
Regulation of monoamine transporters: Role of transporter phosphorylation.
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DOI：
10.1016/j.pharmthera.2010.09.009
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发表时间：
2011-02
影响因子：
13.5
通讯作者：
Jayanthi, Lankupalle D.
中科院分区：
文献类型：
--
作者：
Ramamoorthy, Sammanda;Shippenberg, Toni S.;Jayanthi, Lankupalle D.
Presynaptic biogenic amine transporters mediate reuptake of released amines from the synapse, thus regulating serotonin, dopamine and norepinephrine neurotransmission. Medications utilized in the treatment of depression, attention deficit-hyperactivity disorder and other psychiatric disorders possess high affinity for amine transporters. In addition, amine transporters are targets for psychostimulants. Altered expression of biogenic amine transporters has long been implicated in several psychiatric and degenerative disorders. Therefore, appropriate regulation and maintenance of biogenic amine transporter activity is critical for the maintenance of normal amine homoeostasis. Accumulating evidence suggests that cellular protein kinases and phosphatases regulate amine transporter expression, activity, trafficking and degradation. Amine transporters are phosphoproteins that undergo dynamic control under the influence of various kinase and phosphatase activities. This review presents a brief overview of the role of amine transporter phosphorylation in the regulation of amine transport in the normal and diseased brain. Understanding the molecular mechanisms by which phosphorylation events affect amine transporter activity is essential for understanding the contribution of transporter phosphorylation to the regulation of monoamine neurotransmission and for identifying potential new targets for the treatment of various brain diseases.
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DOI：
10.1124/jpet.102.047134
发表时间：
2003-06-01
影响因子：
3.5
作者：
Ansah, TA;Ramamoorthy, S;Blakely, RD
通讯作者：
Blakely, RD
DOI：
10.1523/jneurosci.5094-09.2010
发表时间：
2010-04-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bowton E;Saunders C;Erreger K;Sakrikar D;Matthies HJ;Sen N;Jessen T;Colbran RJ;Caron MG;Javitch JA;Blakely RD;Galli A
通讯作者：
Galli A
影响因子：
2.9
作者：
BOYD, FT;CLARKE, DW;RAIZADA, MK
通讯作者：
RAIZADA, MK
影响因子：
7.6
作者：
Ahern, TH;Javors, MA;Weinshenker, D
通讯作者：
Weinshenker, D
影响因子：
4.7
作者：
Binda, F;Lute, BJ;Galli, A
通讯作者：
Galli, A