IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS).
IL-18 Signaling Is Essential for Causing Streptococcal Toxic Shock-like Syndrome (STSLS).
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DOI：
10.3390/life12091324
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发表时间：
2022-08-26
期刊：
影响因子：
--
通讯作者：
Zhang A
中科院分区：
文献类型：
--
作者：
Xu L;Zeng Y;Gao P;Lu X;Xia K;Zhou L;Zhang C;Yi C;Zhang A
猪链球菌（Streptococcus suis，S.猪链球菌（Streptococcal toxic shock like syndrome，STSLS）是一种新出现的人畜共患病原体，可引起多种疾病。色葡萄猪SC-19株可引起NOD样受体热蛋白结构域相关蛋白3（NLRP 3）炎性小体过度活化，进而引起细胞因子风暴和STSLS。虽然IL-18是NLRP 3信号传导的下游效应物，但IL-18信号传导对STSLS的作用仍有待阐明。因此，构建il 18 r1基因敲除小鼠并用SC-19株攻击。与WT小鼠相比，在SC-19激发后，在il 18 r −/−小鼠中观察到临床体征和组织损伤减轻以及存活率提高。同时，在感染SC-19的il 18 r-/-小鼠中观察到血液中炎性细胞因子水平的明显降低。因此，IL-18作为NLRP 3炎性小体激活的下游效应物，负责S.提示IL-18/IL-18 R α信号通路可作为STSLS的新靶点。
Streptococcus suis (S. suis) is an emerging zoonotic pathogen that can cause multiple diseases, including streptococcal toxic shock-like syndrome (STSLS). The S. suis SC-19 strain could cause NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome hyperactivation, then induce a cytokine storm and STSLS. Although IL-18 is the downstream effector of NLRP3 signaling, the role of IL-18 signaling on STSLS remains to be elucidated. Thus, il18r1 gene knockout mice were constructed and challenged with the SC-19 strain. Alleviated clinical signs and tissue damages, as well as improved survival were observed in il18r−/− mice compared with the WT mice post-SC-19 challenge. Meanwhile, an obvious decrease in the inflammatory cytokine levels in blood was observed in the il18r-/- mice infected with SC-19. Therefore, IL-18, the downstream effector of NLRP3 inflammasome activation, was responsible for the cytokine storm and STSLS development caused by S. suis, suggesting that IL-18/IL-18Rα signaling could serve as a new target for STSLS.
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