Hospitalizations and emergency department use in Mayo Clinic Biobank participants within the employee and community health medical home.
Hospitalizations and emergency department use in Mayo Clinic Biobank participants within the employee and community health medical home.
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DOI：
10.1016/j.mayocp.2013.06.015
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发表时间：
2013-09
影响因子：
8.9
通讯作者：
Cerhan JR
中科院分区：
文献类型：
--
作者：
Takahashi PY;Ryu E;Olson JE;Anderson KS;Hathcock MA;Haas LR;Naessens JM;Pathak J;Bielinski SJ;Cerhan JR
评价马约诊所生物样本库中的参与者在医院利用率方面对整个员工和社区卫生（ECH）初级保健人群的代表性。从2009年4月1日至2010年12月31日在马约诊所生物库登记的参与者与ECH面板相关联。根据截至2010年12月31日的健康状况数量，将受试者分为风险等级（0-4）。结果确定至2011年12月31日。使用考克斯回归估计住院、ER访视和30天再住院风险的风险比（HR）和95%置信区间（CI），考虑年龄和性别。8，927名生物库参与者是ECH小组的一部分（N= 84，872）。与所有ECH相比，Biobank-ECH参与者更可能是女性（64% vs 55%），年龄更大（中位年龄为58岁vs 47岁），并且0级百分比较低（6% vs 24%）。在Biobank-ECH参与者中，等级（4 vs 0/1）与住院风险（HR=5.8; 95% CI，4.6-7.5）和ER访视（HR=5.4; 95% CI，4.2-6.8）存在强正相关。在所有ECH中观察到住院风险（HR=8.5; 95%CI，7.8-9.3）和ER访视（HR=6.9; 95%CI，6.4-7.5）的相似相关性。与ECH组相比，Biobank-ECH组参与者年龄更大，慢性疾病更多。尽管如此，风险等级与利用结果的相关性相似，支持使用Biobank-ECH参与者来评估初级保健环境中医疗保健结果的生物标志物。
To evaluate the participants in the Mayo Clinic Biobank for their representativeness to the entire Employee and Community Health (ECH) primary care population with regards to hospital utilization. Participants enrolled in the Mayo Clinic Biobank from April 1, 2009, to December 31, 2010, were linked to ECH panels. Subjects were categorized into risk tiers (0–4) based on the number of health conditions as of December 31, 2010. Outcomes were ascertained through December 31, 2011. Hazard ratios (HR) and 95% confidence intervals (CI) for risk of hospitalization, ER visits, and 30-day re-hospitalization were estimated using Cox regression, accounting for age and sex. The 8,927 Biobank participants were part of an ECH panel (N=84,872). Compared to all of ECH, the Biobank-ECH participants were more likely to be female (64% vs 55%), older (median age of 58 years vs 47 years), and have a lower percentage in tier 0 (6% vs 24%). There were strong positive associations of tier (4 vs 0/1) with risk of hospitalization (HR=5.8; 95% CI, 4.6–7.5) and ER visits (HR=5.4; 95% CI, 4.2–6.8), among Biobank-ECH participants. Similar associations for risk of hospitalization (HR=8.5; 95% CI, 7.8–9.3) and ER visits (HR=6.9; 95%CI, 6.4–7.5) were observed for all of ECH. Biobank-ECH participants were older and had more chronic conditions compared to the ECH panel. Nevertheless, the associations of risk tier with utilization outcomes were similar, supporting the use of the Biobank-ECH participants for assessing biomarkers for health care outcomes in the primary care setting.
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影响因子：
3
作者：
Lemke, Klaus W.;Weiner, Jonathan P.;Clark, Jeanne M.
通讯作者：
Clark, Jeanne M.
影响因子：
1.7
作者：
Ridgeway JL;Han LC;Olson JE;Lackore KA;Koenig BA;Beebe TJ;Ziegenfuss JY
通讯作者：
Ziegenfuss JY
影响因子：
9.7
作者：
Weiner, Jonathan P.;Trish, Erin;Lemke, Klaus
通讯作者：
Lemke, Klaus
影响因子：
8.9
作者：
Olson JE;Ryu E;Johnson KJ;Koenig BA;Maschke KJ;Morrisette JA;Liebow M;Takahashi PY;Fredericksen ZS;Sharma RG;Anderson KS;Hathcock MA;Carnahan JA;Pathak J;Lindor NM;Beebe TJ;Thibodeau SN;Cerhan JR
通讯作者：
Cerhan JR
影响因子：
2.8
作者：
Crane, Sarah J.;Tung, Ericka E.;Takahashi, Paul Y.
通讯作者：
Takahashi, Paul Y.