Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses
Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses
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多名成员被诊断患有精神疾病的家庭的不良童年经历
DOI：
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
B. Viswanath
中科院分区：
文献类型：
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作者：
Amala Someshwar;Amala Someshwar;B. Holla;P. Agarwal;A. Thomas;Anand Jose;Boban Joseph;Birudu Raju;H. Karle;M. Muthukumaran;P. Kodancha;Pramod Kumar;P. Reddy;R. Nadella;Sanjay T Naik;S. Mitra;Sreenivasulu Mallappagiri;V. S. Sreeraj;S. Balachander;S. Ganesh;P. Murthy;V. Benegal;Janardhan Y. C. Reddy;S. Jain;J. Mahadevan;B. Viswanath
目的：不良的童年经历与成年后许多精神疾病的发展有关。我们的研究调查了来自有⩾2名患有严重精神疾病的一级亲属（多重家庭）的家庭中的个体的不良童年经历的模式及其与主要精神疾病发病年龄的关系，该研究被确定为正在进行的纵向研究的一部分。方法：我们的样本由来自 215 个家庭的 509 名个体组成。其中，268 人受到影响，即被诊断患有双相情感障碍 (n = 61)、强迫症 (n = 58)、精神分裂症 (n = 52)、物质依赖 (n = 59) 或同时诊断 (n = 38)，而 241 人未受影响（n = 210）或患有其他抑郁症或焦虑症（n = 31）的高危一级亲属。使用不良童年经历国际问卷对所有个人进行评估，并计算不良童年经历暴露总数和严重程度评分。结果：我们发现，在我们的样本中，受影响的男性作为一个群体，有最大的不良童年经历暴露和严重程度评分。按性别拟合的考克斯混合效应模型显示，较高的童年不良经历严重程度总分与男性较早发病的精神病诊断风险显着增加相关。评估诊断相互作用的类似模型显示，强迫症和物质依赖的发病年龄较早，但精神分裂症和双相情感障碍则不然。结论：我们的研究表明，对于男性和被诊断患有强迫症和物质依赖的个人来说，不良的童年经历与主要精神疾病的早期发病有关。对这些家庭的一级亲属正在进行的纵向评估有望确定这种关系背后的机制。
Objective: Adverse childhood experiences are linked to the development of a number of psychiatric illnesses in adulthood. Our study examined the pattern of adverse childhood experiences and their relation to the age of onset of major psychiatric conditions in individuals from families that had ⩾2 first-degree relatives with major psychiatric conditions (multiplex families), identified as part of an ongoing longitudinal study. Methods: Our sample consisted of 509 individuals from 215 families. Of these, 268 were affected, i.e., diagnosed with bipolar disorder (n = 61), obsessive–compulsive disorder (n = 58), schizophrenia (n = 52), substance dependence (n = 59) or co-occurring diagnoses (n = 38), while 241 were at-risk first-degree relatives who were either unaffected (n = 210) or had other depressive or anxiety disorders (n = 31). All individuals were evaluated using the Adverse Childhood Experiences – International Questionnaire and total adverse childhood experiences exposure and severity scores were calculated. Results: It was seen that affected males, as a group, had the greatest adverse childhood experiences exposure and severity scores in our sample. A Cox mixed effects model fit by gender revealed that a higher total adverse childhood experiences severity score was associated with significantly increased risk for an earlier age of onset of psychiatric diagnoses in males. A similar model that evaluated the interaction of diagnosis revealed an earlier age of onset in obsessive–compulsive disorder and substance dependence, but not in schizophrenia and bipolar disorder. Conclusion: Our study indicates that adverse childhood experiences were associated with an earlier onset of major psychiatric conditions in men and individuals diagnosed with obsessive–compulsive disorder and substance dependence. Ongoing longitudinal assessments in first-degree relatives from these families are expected to identify mechanisms underlying this relationship.
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影响因子：
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作者：
Merikangas, KR;Stolar, M;Rounsaville, BJ
通讯作者：
Rounsaville, BJ
影响因子：
1.7
作者：
Ducci, Francesca;Goldman, David
通讯作者：
Goldman, David
影响因子：
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作者：
McGuffin, P;Rijsdijk, F;Cardno, A
通讯作者：
Cardno, A
DOI：
10.1111/j.1469-7610.2006.01687.x
发表时间：
2007-02-01
影响因子：
7.6
作者：
Lin, Haiqun;Katsovich, Liliya;Leckman, James F.
通讯作者：
Leckman, James F.
影响因子：
4.8
作者：
Mersky JP;Topitzes J;Reynolds AJ
通讯作者：
Reynolds AJ