Activation chemistry drives the emergence of functionalised protocells.
Activation chemistry drives the emergence of functionalised protocells.
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DOI：
10.1039/d0sc04506c
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发表时间：
2020-10-02
期刊：
影响因子：
8.4
通讯作者：
Sutherland JD
中科院分区：
文献类型：
--
作者：
Bonfio C;Russell DA;Green NJ;Mariani A;Sutherland JD
最简单的细胞的复杂性表明，需要探索益生元混合物的化学性质，以了解导致生命出现的复杂的益生元反应网络。早期的细胞可能依赖于相容和相互连接的化学物质来连接RNA，肽和膜。在这里，我们表明，几种类型的囊泡，prebiotically合理的两亲物的混合物组成，自发形成和维持甲基异腈介导的氨基酸，肽和核苷酸的激活。活化化学还驱动反应性单酰基甘油磷酸酯有利地转化为惰性环磷脂，从而支持它们作为原始细胞的主要成分的潜在作用。此外，基于脂肪酸的囊泡内的益生元构建块的活化产生能够定位于原始膜并使原始膜功能化的脂化物质。我们的研究结果描述了一个潜在的益生元场景，其中原始细胞的成分经历激活，并提供可能增加原始细胞功能的新物种。最简单的细胞的复杂性表明，需要探索益生元混合物的化学性质，以了解导致生命出现的复杂的益生元反应网络。
The complexity of the simplest conceivable cell suggests that the chemistry of prebiotic mixtures needs to be explored to understand the intricate network of prebiotic reactions that led to the emergence of life. Early cells probably relied upon compatible and interconnected chemistries to link RNA, peptides and membranes. Here we show that several types of vesicles, composed of prebiotically plausible mixtures of amphiphiles, spontaneously form and sustain the methyl isocyanide-mediated activation of amino acids, peptides and nucleotides. Activation chemistry also drives the advantageous conversion of reactive monoacylglycerol phosphates into inert cyclophospholipids, thus supporting their potential role as major constituents of protocells. Moreover, activation of prebiotic building blocks within fatty acid-based vesicles yields lipidated species capable of localising to and functionalising primitive membranes. Our findings describe a potentially prebiotic scenario in which the components of primitive cells undergo activation and provide new species that might have enabled an increase in the functionality of protocells. The complexity of the simplest conceivable cell suggests that the chemistry of prebiotic mixtures needs to be explored to understand the intricate network of prebiotic reactions that led to the emergence of life.
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