Chemical-assisted bonding of thermoplastics/elastomer for fabricating microfluidic valves.
Chemical-assisted bonding of thermoplastics/elastomer for fabricating microfluidic valves.
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DOI：
10.1021/ac101999w
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发表时间：
2011-01-01
影响因子：
7.4
通讯作者：
Fan, Z. Hugh
中科院分区：
文献类型：
--
作者：
Gu, Pan;Liu, Ke;Chen, Hong;Nishida, Toshikazu;Fan, Z. Hugh
热塑性塑料如环烯烃共聚物（COC）和聚甲基丙烯酸甲酯（PMMA）已经越来越多地用于制造微流体装置。然而，最先进的微阀技术是基于聚二甲基硅氧烷（PDMS）的三层结构。为了将这样的阀与基于热塑性塑料的微流体装置集成，必须开发用于热塑性塑料/PDMS的结合方法。我们在这里报告了一种方法来键合COC与PDMS通过表面活化电晕放电，表面改性，使用3-（三甲氧基硅基）丙基甲基丙烯酸酯（TMSPMA），和热退火。该方法也适用于PMMA。热塑性塑料和PDMS之间的粘合强度由剥离力表示，剥离力使用国际标准化组织（ISO）建立的方法测量。结合强度的测量提供了一个客观和定量的指标，协议优化，以及与其他PDMS相关的键合方法的比较。利用优化的键合条件，在COC/PDMS/COC器件中制备了两个阀阵列，并成功地演示了阀的关闭/打开的循环操作。含瓣膜的器械可承受100 psi（~689 KPa）压力，无分层。此外，我们将这种阀门阵列集成在用于蛋白质分离的装置中，并在阀门存在下证明了等电聚焦。
Thermoplastics such as cyclic olefin copolymer (COC) and polymethylmethacrylate (PMMA) have been increasingly used in fabricating microfluidic devices. However, the state-of-the-art microvalve technology is a polydimethylsiloxane (PDMS)-based three-layer structure. In order to integrate such a valve with a thermoplastics-based microfluidic device, a bonding method for thermoplastics/PDMS must be developed. We report here a method to bond COC with PDMS through surface activation by corona discharge, surface modification using 3-(trimethoxysilyl)propyl methacrylate (TMSPMA), and thermal annealing. The method is also applicable to PMMA. The bonding strength between thermoplastics and PDMS was represented by the peeling force, which was measured using a method established by the International Organization for Standardization (ISO). The bonding strength measurement offered an objective and quantitative indicator for protocol optimization, as well as comparison with other PDMS-associated bonding methods. Using optimized bonding conditions, two valve arrays were fabricated in a COC/PDMS/COC device and cyclic operations of valve closing/opening were successfully demonstrated. The valve-containing devices withstood 100 psi (~689 KPa) without delamination. Further, we integrated such valve arrays in a device for protein separation and demonstrated isoelectric focusing in the presence of valves.
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影响因子：
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作者：
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